Isotretinoin
Treatment for Acne
Typical Dosage: 0.5-1 mg/kg/day
Effectiveness
90%
Safety Score
50%
Clinical Trials
45
Participants
75K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
0.5-1 mg/kg/day
Time to Effect
1-2 months
Treatment Duration
4-6 months
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1(Treat 1 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,000
Monitoring:$1,350
Side Effect Mgmt:$150
Total Annual:$2,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$2,840.91
Cost per Remission
$3,571.43
Isotretinoin Outcomes
for Acne
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+88%
Remission Rate
+70%
Common Side Effects
Dry lips
+95%
Dry skin
+85%
Dry eyes
+60%
Nosebleeds
+40%
Muscle/joint aches
+30%
Photosensitivity
+25%
Elevated triglycerides
+20%
Elevated liver enzymes
+5%
Mood changes/depression
+2%
Teratogenicity
+100%
Active Clinical Trials
2 active trials recruiting for Isotretinoin in Acne
Assessment of Serum Catestatin Level in Acne Vulgaris Patients
NCT07054398RECRUITINGNA
60 participants
INTERVENTIONAL
Aswān, Egypt
Started: Jan 10, 2025
Weekly Isotretinoin vs Tetracycline for Moderate Acne
NCT06225570RECRUITINGEARLY_PHASE1
50 participants
INTERVENTIONAL
Charleston, United States
Started: Feb 1, 2025
Completed Clinical Trials
14 completed trials for Isotretinoin in Acne
Study of Two Dosages of Roaccutane in Cystic Acne
NCT07228481COMPLETEDPHASE4
91 participants
INTERVENTIONAL
Started: Jun 26, 2001
ABSORICA in Patients With Severe Recalcitrant Nodular Acne
NCT02457520COMPLETEDPHASE4
201 participants
INTERVENTIONAL
San Antonio, United States
Started: Jan 21, 2015
Effects of Roaccutane on Ca, P, PTH and Vitamin D Metabolites in the Treatment of Sever Acne
NCT00416585COMPLETEDPHASE1
30 participants
INTERVENTIONAL
Tehran, Iran
Started: Oct 1, 2005
Effect of Systemic Isotretinoin on Serum Irisin Level in Acne Vulgaris Patients
NCT05869188COMPLETEDNA
60 participants
INTERVENTIONAL
Qina, Egypt
Started: Jun 1, 2023
Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.
NCT05529888COMPLETEDPHASE4
60 participants
INTERVENTIONAL
Aswān, Egypt
Started: Dec 15, 2020
Investigation of the Effect of Oral Isotretinoin on Skin Thickness and Elasticity in Patients With Atrophic Acne Scar
NCT05413200COMPLETED
30 participants
OBSERVATIONAL
Istanbul, Turkey (Türkiye)
Started: Nov 1, 2021
Weekly Isotretinoin Therapy Study
NCT04594759COMPLETEDPHASE1, PHASE2
22 participants
INTERVENTIONAL
Charleston, United States
Started: Nov 11, 2020
A Pilot Study of the Effects of Isotretinoin on Cognition, Learning and Memory
NCT01404130COMPLETEDPHASE4
18 participants
INTERVENTIONAL
Aberdeen, United Kingdom
Started: Sep 1, 2008
Acne Remission Maintenance by Weekend Systemic Isotretinoin
NCT06451237COMPLETEDPHASE3
60 participants
INTERVENTIONAL
Alexandria, Egypt
Started: Jan 20, 2018
Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
NCT06242288COMPLETEDPHASE3
40 participants
INTERVENTIONAL
Tanta, Egypt
Started: Jan 30, 2024
Efficacy and Safety of CIP-Isotretinoin in Patients With Severe Recalcitrant Nodular Acne
NCT00975143COMPLETEDPHASE3
925 participants
INTERVENTIONAL
Birmingham, United States +48 more
Started: Sep 1, 2009
De Novo Lipogenesis of Sebaceous Glands in Acne
NCT02620813COMPLETEDEARLY_PHASE1
32 participants
INTERVENTIONAL
Davis, United States +1 more
Started: Oct 1, 2015
A Study to Determine Bioequivalence of Isotretinoin in Healthy Male Subjects Under Fed Condition
NCT02498288COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Monterrey, Mexico
Started: May 31, 2013
Bioequivalence Study for an Isotretinoin
NCT01863615COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Monterrey, Mexico
Started: Aug 26, 2011
Showing 20 of 47 total trials