Topical Retinoids (e.g., Adapalene, Tretinoin)
Treatment for Acne
Typical Dosage: Applied once daily
Effectiveness
78%
Safety Score
80%
Clinical Trials
2,000
Participants
200K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe
Treatment Details
Dosage Range
Applied once daily
Time to Effect
4-12 weeks
Treatment Duration
Long-term (years)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
3(Treat 3 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$400
Cost per Remission
$545.45
Prescription Access Economics
Annual Societal Loss per Patient
$280
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$30/year
Prior auth, claims
Rx Price
$150/year
Potential OTC Price
$60/year
Estimated if OTC available
Early Treatment Benefit
+0.10 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWTopical Retinoids (e.g., Adapalene, Tretinoin) Outcomes
for Acne
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+75%
Remission Rate
+55%
Common Side Effects
Dryness
+30%
Redness
+30%
Peeling
+20%
Burning/Stinging
+15%
Photosensitivity
+20%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov