Methylphenidate (Ritalin, Concerta)
Treatment for Adhd
Typical Dosage: 10-60mg daily (methylphenidate equivalent), tailored to individual
Effectiveness
85%
Safety Score
60%
Clinical Trials
341
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
10-60mg daily (methylphenidate equivalent), tailored to individual
Time to Effect
Immediate (within 30-60 minutes for IR, 1-2 hours for ER)
Treatment Duration
Lifetime (as needed)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
5(Treat 5 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$800
Monitoring:$300
Side Effect Mgmt:$75
Total Annual:$1,175
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$15,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$1,567
Cost per Remission
$2,937.5
Methylphenidate (Ritalin, Concerta) Outcomes
for Adhd
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+75%
Remission Rate
+40%
Common Side Effects
Insomnia
+25%
Decreased appetite/weight loss
+25%
Headache
+15%
Abdominal pain
+12%
Irritability/mood swings
+8%
Increased heart rate/blood pressure
+8%
Active Clinical Trials
2 active trials recruiting for Methylphenidate (Ritalin, Concerta) in Adhd
Medication Treatment of ADHD in Pediatric Epilepsy
NCT07594652RECRUITINGPHASE4
25 participants
INTERVENTIONAL
Baltimore, United States
Started: May 29, 2026
Benefits of ADHD Treatment in Detained People
NCT05842330RECRUITINGPHASE3
150 participants
INTERVENTIONAL
Geneva, Switzerland
Started: Jan 1, 2024
Completed Clinical Trials
15 completed trials for Methylphenidate (Ritalin, Concerta) in Adhd
Study of the Effect of Individualizing Daytrana Wear-times on Sleep in Children With ADHD
NCT00989950COMPLETEDNA
26 participants
INTERVENTIONAL
Springfield, United States
Started: Dec 1, 2009
Efficacy and Safety Study of Methylphenidate Hydrochloride Extended Release in Adults With Childhood-onset Attention Deficit/Hyperactivity Disorder (ADHD)
NCT01259492COMPLETEDPHASE3
725 participants
INTERVENTIONAL
Little Rock, United States +67 more
Started: Nov 1, 2010
Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study
NCT02255565COMPLETEDPHASE4
36 participants
INTERVENTIONAL
Seattle, United States
Started: Sep 1, 2014
Concerta (Methylphenidate) -To-Generic Switch Study
NCT02730572COMPLETED
1.46K participants
OBSERVATIONAL
Started: Sep 1, 2015
Evaluating Treatment of ADHD in Children With Down Syndrome
NCT04219280COMPLETEDPHASE4
44 participants
INTERVENTIONAL
Sacramento, United States +3 more
Started: Oct 2, 2020
Characterization of Dermal Reactions in Pediatric Patients With ADHD Using DAYTRANA
NCT00434213COMPLETEDPHASE4
309 participants
INTERVENTIONAL
Scottsdale, United States +28 more
Started: Jan 1, 2007
Open-label Extension Evaluating Methylphenidate Hydrochloride Extended Release in Adults With Attention Deficit/Hyperactivity Disorder
NCT01338818COMPLETEDPHASE3
299 participants
INTERVENTIONAL
Little Rock, United States +47 more
Started: Apr 1, 2011
Efficacy of Concerta in Treating ADHD in Mothers of Children With ADHD
NCT00318981COMPLETEDPHASE4
40 participants
INTERVENTIONAL
Fairfax, United States
Started: Dec 1, 2004
Effects of Ritalin on Postural Stability of Hyper Active Children
NCT00485797COMPLETEDNA
30 participants
INTERVENTIONAL
Beersheba, Israel
Started: Oct 1, 2007
Prevention of Cigarette Smoking in Attention Deficit Hyperactivity Disorder (ADHD) Youth With Concerta
NCT00181714COMPLETEDPHASE4
203 participants
INTERVENTIONAL
Cambridge, United States
Started: Nov 1, 2003
OT and Social Cognition in Children With ADHD: Impact of MPH
NCT03788902COMPLETEDNA
90 participants
INTERVENTIONAL
Started: Feb 1, 2014
Evaluating the Methylphenidate Patch to Treat Former Stimulant Users With ADHD
NCT00780208COMPLETEDNA
14 participants
INTERVENTIONAL
Charleston, United States
Started: Apr 1, 2007
An Efficacy Study of Osmotic Release Oral System (OROS) Methylphenidate in Participants With Attention-Deficit/Hyperactivity Disorder (ADHD)
NCT01060150COMPLETEDPHASE4
115 participants
INTERVENTIONAL
Started: Jul 1, 2008
SPD544 High Strength Bioequivalence Study
NCT01183234COMPLETEDPHASE1
28 participants
INTERVENTIONAL
London, United Kingdom
Started: Aug 27, 2010
Biomarkers of ADHD Treatment Response
NCT05650775COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Brookline, United States
Started: Feb 17, 2023
Showing 20 of 353 total trials