Melarsoprol
Treatment for African Trypanosomiasis
Typical Dosage: 1.8-3.6 mg/kg IV daily for 3-4 days, repeated after 7-10 days, total 3 series
Effectiveness
85%
Safety Score
25%
Clinical Trials
1
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
1.8-3.6 mg/kg IV daily for 3-4 days, repeated after 7-10 days, total 3 series
Time to Effect
Within days, full effect after treatment completion
Treatment Duration
3.5 weeks (3 series of 3-4 daily injections)
Evidence Quality
MODERATENumber Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$7,000
Side Effect Mgmt:$2,000
Total Annual:$9,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POORQALYs Gained
2
Outcome-Based Costs
Cost per Responder
$10,824
Cost per Remission
$11,500
Melarsoprol Outcomes
for African Trypanosomiasis
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Reactive encephalopathy
+7%
Peripheral neuropathy
+10%
Myocardial damage
+5%
Vomiting
+50%
Death from side effects
+5%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov