DFDA

Disulfiram

Treatment for Alcohol Use Disorders

Typical Dosage: 250-500mg daily

Effectiveness
30%
Safety Score
35%
Clinical Trials
8
Participants
4K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
35
DangerousModerateSafe
Treatment Details
Dosage Range
250-500mg daily
Time to Effect
Within hours of first dose
Treatment Duration
6-12 months (adherence dependent)
Evidence Quality
MODERATE
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$350
Monitoring:$1,000
Side Effect Mgmt:$300
Total Annual:$1,650
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$50,000/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$5,500
Cost per Remission
$8,250
Prescription Access Economics
Risk Assessment
Misuse Risk
HIGH
Missed Diagnosis Risk
LOW
Requires Monitoring
Yes
Needs lab work/checkups
Disulfiram Outcomes

for Alcohol Use Disorders

Efficacy Outcomes
Overall Effectiveness
+30%
Response Rate
+30%
Remission Rate
+20%
Common Side Effects
Metallic taste
+15%
Fatigue
+8%
Skin rash
+4%
Disulfiram-ethanol reaction (with alcohol)
+100%
Hepatotoxicity (rare)
+0.5%

Sources:

researchgate.net
semanticscholar.org
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
3 active trials recruiting for Disulfiram in Alcohol Use Disorders

Anxiety During Abstinence in AUD

NCT06793488RECRUITINGEARLY_PHASE1
View Study
60 participants
INTERVENTIONAL
New York, United States
Started: Sep 15, 2025

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

NCT06319872RECRUITINGPHASE1
View Study
15 participants
INTERVENTIONAL
Rochester, United States
Started: May 19, 2025

Combining a Smartphone App With Medications to Manage Heavy Drinking

NCT06303778RECRUITINGNA
View Study
330 participants
INTERVENTIONAL
Phoenix, United States +14 more
Started: Nov 1, 2024
Completed Clinical Trials
3 completed trials for Disulfiram in Alcohol Use Disorders

Neural Mechanisms of Disulfiram Effects

NCT02735577COMPLETEDPHASE4
View Study
7 participants
INTERVENTIONAL
New York, United States
Started: Mar 1, 2016

Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder

NCT04502589COMPLETEDPHASE1, PHASE2
View Study
4 participants
INTERVENTIONAL
Richmond, United States
Started: Oct 15, 2020

A Targeted, Real-Time, Technology-Supported Intervention for Patients With Alcohol Use Disorder on Disulfiram

NCT03543735COMPLETEDNA
View Study
50 participants
INTERVENTIONAL
Providence, United States
Started: Nov 29, 2018