Oral Naltrexone
Treatment for Alcohol Use Disorders
Typical Dosage: 50mg daily
Effectiveness
35%
Safety Score
62%
Clinical Trials
14
Participants
18K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
62
DangerousModerateSafe
Treatment Details
Dosage Range
50mg daily
Time to Effect
1-2 weeks
Treatment Duration
3-12 months
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$750
Side Effect Mgmt:$100
Total Annual:$1,350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$30,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$3,857
Cost per Remission
$6,750
Prescription Access Economics
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWRequires Monitoring
YesNeeds lab work/checkups
Oral Naltrexone Outcomes
for Alcohol Use Disorders
Efficacy Outcomes
Overall Effectiveness
+35%
Response Rate
+35%
Remission Rate
+20%
Common Side Effects
Nausea
+15%
Headache
+10%
Dizziness
+7%
Fatigue
+7%
Sources:
Active Clinical Trials
4 active trials recruiting for Oral Naltrexone in Alcohol Use Disorders
Emergency Department-Initiated Medications for Alcohol Use Disorder
NCT05827159RECRUITINGPHASE3
240 participants
INTERVENTIONAL
New Haven, United States
Started: Aug 17, 2024
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
NCT06426303RECRUITINGPHASE4
100 participants
INTERVENTIONAL
Portland, United States
Started: May 2, 2024
Combination Therapy for Alcohol Use Disorder
NCT07249554NOT YET RECRUITINGPHASE2
45 participants
INTERVENTIONAL
Havre de Grace, United States
Started: Sep 1, 2026
Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol
NCT07269873RECRUITINGPHASE1
30 participants
INTERVENTIONAL
Miami, United States
Started: Mar 16, 2026
Completed Clinical Trials
10 completed trials for Oral Naltrexone in Alcohol Use Disorders
ED Initiated Oral Naltrexone for AUD
NCT04817410COMPLETEDPHASE1
30 participants
INTERVENTIONAL
New York, United States
Started: Sep 28, 2021
Naltrexone for Medication Compliance Among HIV-infected Men With Alcohol Use Disorder
NCT01377168COMPLETEDPHASE4
159 participants
INTERVENTIONAL
Lima, Peru
Started: May 1, 2014
Alcohol Disorder hOsPital Treatment Trial
NCT02478489COMPLETEDPHASE4
248 participants
INTERVENTIONAL
Boston, United States
Started: Jun 1, 2016
Treatment Strategy for Alcohol Use Disorders in Veterans With TBI
NCT01342549COMPLETEDPHASE3
62 participants
INTERVENTIONAL
Iowa City, United States +1 more
Started: Sep 1, 2011
Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
NCT05093296COMPLETEDPHASE2, PHASE3
62 participants
INTERVENTIONAL
Mannheim, Germany
Started: Dec 2, 2021
Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, Russia
NCT00675961COMPLETEDNA
400 participants
INTERVENTIONAL
Tomsk, Russia
Started: Jan 1, 2007
Targeted Naltrexone for Problem Drinkers
NCT00369408COMPLETEDPHASE4
163 participants
INTERVENTIONAL
Farmington, United States
Started: Jun 1, 2003
Integrated Digital Intervention for Alcohol Use Disorder
NCT05748639COMPLETEDPHASE2, PHASE3
242 participants
INTERVENTIONAL
New York, United States
Started: Jan 1, 2023
Medication and Counseling for Controlled Drinking (Project SMART)
NCT00444418COMPLETEDPHASE3
200 participants
INTERVENTIONAL
New York, United States
Started: Apr 1, 2006
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
NCT03718104COMPLETED
46 participants
OBSERVATIONAL
Boston, United States +1 more
Started: Dec 1, 2018