DFDA

Topiramate (Off-label)

Treatment for Alcohol Use Disorders

Typical Dosage: 100-300mg daily (titrated)

Effectiveness
38%
Safety Score
60%
Clinical Trials
50
Participants
8K

Comparative Safety Scale(Higher is safer)

Cyanide☠ī¸
Meth💀
CigarettesđŸšŦ
Chemoâ˜ĸī¸
AlcoholđŸē
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
100-300mg daily (titrated)
Time to Effect
2-4 weeks
Treatment Duration
6-12 months
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$600
Side Effect Mgmt:$200
Total Annual:$1,300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$45,000/QALY
QALYs Gained
0.12
Outcome-Based Costs
Cost per Responder
$3,421
Cost per Remission
$6,500
Prescription Access Economics
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
LOW
Requires Monitoring
Yes
Needs lab work/checkups
Topiramate (Off-label) Outcomes

for Alcohol Use Disorders

Efficacy Outcomes
Overall Effectiveness
+38%
Response Rate
+38%
Remission Rate
+20%
Common Side Effects
Paresthesia
+40%
Cognitive slowing
+15%
Anorexia/Weight loss
+12%
Fatigue
+12%

Sources:

frontiersin.org
nih.gov
researchgate.net

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov