Intranasal Antihistamines (e.g., Azelastine)
Treatment for Allergic Rhinitis
Typical Dosage: 1-2 sprays per nostril twice daily
Effectiveness
80%
Safety Score
77%
Clinical Trials
100
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
77
DangerousModerateSafe
Treatment Details
Dosage Range
1-2 sprays per nostril twice daily
Time to Effect
15-30 minutes
Treatment Duration
Seasonal or daily as needed
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$360
Monitoring:$25
Side Effect Mgmt:$10
Total Annual:$395
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$548.61
Cost per Remission
$1,316.67
Comparison vs Intranasal Corticosteroids
Cost Difference
+$180/year
More expensive
QALY Difference
-0.01 QALYs
Worse outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$375
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$75/year
Travel + wait time
Insurance Admin Cost
$40/year
Prior auth, claims
Rx Price
$360/year
Potential OTC Price
$300/year
Estimated if OTC available
Early Treatment Benefit
+0.02 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWIntranasal Antihistamines (e.g., Azelastine) Outcomes
for Allergic Rhinitis
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+72%
Remission Rate
+30%
Common Side Effects
Bitter taste/dysgeusia
+15%
Nasal irritation/bleeding
+7%
Headache
+8%
Drowsiness
+3%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov