DFDA

NSAIDs (e.g., Diclofenac, Naproxen)

Treatment for Ankylosing Spondylitis

Typical Dosage: Naproxen 250-500mg BID; Diclofenac 50mg BID/TID or 75mg XR daily/BID

Effectiveness
45%
Safety Score
75%
Clinical Trials
1,000
Participants
1M

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
Naproxen 250-500mg BID; Diclofenac 50mg BID/TID or 75mg XR daily/BID
Time to Effect
Immediate to 1 week
Treatment Duration
Lifetime (intermittent or continuous)
Evidence Quality
HIGH
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
150(Treat 150 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$100
Side Effect Mgmt:$100
Total Annual:$400
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$1,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$533
Cost per Remission
$4,000
Prescription Access EconomicsOTC Available
Annual Societal Loss per Patient
$460
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$70/year
Travel + wait time
Insurance Admin Cost
$40/year
Prior auth, claims
Rx Price
$200/year
Potential OTC Price
$100/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
MODERATE
Missed Diagnosis Risk
LOW
Requires Monitoring
Yes
Needs lab work/checkups
NSAIDs (e.g., Diclofenac, Naproxen) Outcomes

for Ankylosing Spondylitis

Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+75%
Remission Rate
+10%
Common Side Effects
Gastrointestinal upset
+15%
Fluid retention
+5%
Increased blood pressure
+5%
Gastric ulcers/bleeding
+3%
Renal impairment
+1%
Cardiovascular events
+0.5%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov