Olanzapine
Treatment for Anorexia Nervosa
Typical Dosage: 2.5-10 mg daily
Effectiveness
45%
Safety Score
40%
Clinical Trials
9
Participants
1K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
2.5-10 mg daily
Time to Effect
2-3 months
Treatment Duration
3-6 months
Evidence Quality
LOWNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
60%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$900
Monitoring:$700
Side Effect Mgmt:$700
Total Annual:$2,300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POORQALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$6,571
Olanzapine Outcomes
for Anorexia Nervosa
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+35%
Common Side Effects
Weight gain
+40%
Sedation
+30%
Increased appetite
+25%
Metabolic syndrome
+15%
Sources:
Active Clinical Trials
1 active trial recruiting for Olanzapine in Anorexia Nervosa
Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients with Advanced Stage Cancer
NCT05170919ENROLLING BY INVITATIONPHASE2
170 participants
INTERVENTIONAL
Englewood, United States
Started: Jan 20, 2022
Completed Clinical Trials
7 completed trials for Olanzapine in Anorexia Nervosa
Olanzapine Versus Placebo for Outpatients With Anorexia Nervosa
NCT01170117COMPLETEDNA
152 participants
INTERVENTIONAL
Baltimore, United States +4 more
Started: Aug 1, 2010
Olanzapine in the Treatment of Anorexia Nervosa
NCT00592930COMPLETEDPHASE4
20 participants
INTERVENTIONAL
New Hyde Park, United States
Started: Jun 1, 2000
Olanzapine in the Treatment of Patients With Anorexia Nervosa
NCT00260962COMPLETEDPHASE2
34 participants
INTERVENTIONAL
Ottawa, Canada
Started: Sep 1, 2000
Effectiveness of Olanzapine Versus Placebo in Treating Outpatients With Anorexia Nervosa
NCT00692185COMPLETEDPHASE2
23 participants
INTERVENTIONAL
New York, United States
Started: Oct 1, 2005
Therapeutic Drug Monitoring in Child and Adolescent Psychiatry
NCT01057329COMPLETED
200 participants
OBSERVATIONAL
Vienna, Austria
Started: Jan 1, 2010
Neurobiology of Eating Disorders Treatments
NCT01990755COMPLETEDNA
112 participants
INTERVENTIONAL
Garda, Italy
Started: May 1, 2010
Effectiveness of Atypical Antipsychotic Medication for Outpatients With Anorexia Nervosa
NCT00685334COMPLETEDPHASE4
22 participants
INTERVENTIONAL
New York, United States +1 more
Started: Nov 1, 2003