Duloxetine (SNRI)
Treatment for Anxiety Disorder
Typical Dosage: 30-120mg daily
Effectiveness
72%
Safety Score
60%
Clinical Trials
3
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
30-120mg daily
Time to Effect
2-4 weeks
Treatment Duration
6-12 months, often longer
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
11(Treat 11 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$450
Monitoring:$200
Side Effect Mgmt:$100
Total Annual:$750
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
0.22
Outcome-Based Costs
Cost per Responder
$1,500
Cost per Remission
$2,679
Comparison vs No Treatment
Cost Difference
+$750/year
More expensive
QALY Difference
+0.22 QALYs
Better outcomes
Dominance
No dominance
Duloxetine (SNRI) Outcomes
for Anxiety Disorder
Efficacy Outcomes
Overall Effectiveness
+72%
Response Rate
+50%
Remission Rate
+28%
Common Side Effects
Nausea
+20%
Dry mouth
+15%
Constipation
+10%
Insomnia
+10%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
2 completed trials for Duloxetine (SNRI) in Anxiety Disorder
Duloxetine for Social Anxiety Disorder: Prediction of Long Term Outcome
NCT00114127COMPLETEDPHASE3
28 participants
INTERVENTIONAL
Boston, United States
Started: Jun 1, 2004
Efficacy of Online CBT for GAD Compared to Pharmaceutical Interventions
NCT04478526COMPLETEDNA
115 participants
INTERVENTIONAL
Kingston, Canada
Started: Apr 29, 2020