Fluticasone/Salmeterol
Treatment for Asthma
Typical Dosage: 100/50 mcg - 500/50 mcg twice daily
Effectiveness
90%
Safety Score
55%
Clinical Trials
189
Participants
75K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
100/50 mcg - 500/50 mcg twice daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$900
Monitoring:$550
Side Effect Mgmt:$75
Total Annual:$1,525
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$30,000/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$1,794
Cost per Remission
$3,389
Comparison vs Fluticasone propionate (ICS alone)
Cost Difference
+$525/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Fluticasone/Salmeterol Outcomes
for Asthma
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+85%
Remission Rate
+45%
Common Side Effects
Headache
+15%
Upper respiratory tract infection
+12%
Pharyngitis
+8%
Oropharyngeal candidiasis (thrush)
+7%
Tremor
+3%
Active Clinical Trials
1 active trial recruiting for Fluticasone/Salmeterol in Asthma
A Study to Evaluate the Efficacy and Safety of QVM149 (Indacaterol Acetate / Glycopyrronium Bromide / Mometasone Furoate) Versus Salmeterol Xinafoate/Fluticasone Propionate in Children From 12 Years to Less Than 18 Years of Age With Asthma.
NCT05776927RECRUITINGPHASE3
188 participants
INTERVENTIONAL
Strasbourg, France +18 more
Started: Aug 4, 2026
Completed Clinical Trials
17 completed trials for Fluticasone/Salmeterol in Asthma
Comparing Salmeterol/Fluticasone Easyhaler and Seretide Diskus (SAIMI)
NCT03238482COMPLETEDPHASE1
64 participants
INTERVENTIONAL
Espoo, Finland
Started: Aug 16, 2017
A Study In Pediatric Subjects With Asthma Using ADVAIR HFA, ADVAIR HFA With Spacer, And ADVAIR DISKUS
NCT00400608COMPLETEDPHASE4
28 participants
INTERVENTIONAL
Huntington Beach, United States +2 more
Started: Oct 1, 2006
Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma
NCT00830505COMPLETEDPHASE4
38 participants
INTERVENTIONAL
Dundee, United Kingdom
Started: Apr 1, 2009
Interactive Acute Smooth Muscle Effects of Salmeterol and Fluticasone in the Airway
NCT01231230COMPLETEDNA
14 participants
INTERVENTIONAL
Started: May 1, 2007
A 12-Week Study To Assess The Safety Of Fluticasone Propionate/Salmeterol 100/50 Hydrofluoroalkane (HFA) Versus Fluticasone Propionate 100 HFA In Children With Asthma
NCT00441441COMPLETEDPHASE3
351 participants
INTERVENTIONAL
Huntington Beach, United States +54 more
Started: Feb 1, 2007
Clinical Assessment Of GW815SF HFA MDI In Pediatric Patients With Bronchial Asthma
NCT00448435COMPLETEDPHASE3
51 participants
INTERVENTIONAL
Chiba, Japan +7 more
Started: Apr 1, 2007
Seretide Versus Flixotide In Asthmatic Children Not Controlled By Inhaled Corticosteroids
NCT00353873COMPLETEDPHASE4
506 participants
INTERVENTIONAL
Bruges, Belgium +64 more
Started: Nov 18, 2005
Viapaed Study In Children And Adolescents With Asthma
NCT00315744COMPLETEDPHASE4
285 participants
INTERVENTIONAL
Bad Krozingen, Germany +97 more
Started: Nov 4, 2004
Long-acting Beta Agonist Step Down Study
NCT01437995COMPLETEDPHASE4
459 participants
INTERVENTIONAL
Tucson, United States +18 more
Started: Mar 1, 2012
Study Of Asthma And Genetics In Patients To Be Treated With Fluticasone Propionate/Salmeterol Or Salmeterol Xinafoate
NCT00102882COMPLETEDPHASE4
547 participants
INTERVENTIONAL
Mobile, United States +90 more
Started: Oct 1, 2004
The Effects of Montelukast on Smokers With Asthma
NCT00712335COMPLETEDPHASE4
105 participants
INTERVENTIONAL
Seoul, South Korea
Started: Feb 1, 2007
Study to Determine the Pharmacokinetics and Tolerability of Fluticasone Propionate MDPI and Fluticasone Propionate/Salmeterol MDPI Compared to High Strength FLOVENT® DISKUS® and ADVAIR® DISKUS® in Patients With Persistent Asthma 12 Years of Age and Older
NCT02437604COMPLETEDPHASE1
43 participants
INTERVENTIONAL
Raleigh, United States +2 more
Started: May 1, 2015
Effects on Small Airways of Two Long-term Extrafine Treatments in Asthma
NCT01255579COMPLETEDPHASE4
10 participants
INTERVENTIONAL
Started: Jul 1, 2007
Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
NCT00736801COMPLETEDNA
35 participants
INTERVENTIONAL
Rostock, Germany
Started: Sep 1, 2005
Dose-Response of Salmeterol in Children
NCT01907334COMPLETEDPHASE4
10 participants
INTERVENTIONAL
Gainesville, United States
Started: Aug 1, 2013
A Double Blind Open Label Comparator Study to Compare Treatments in 4 to 11 Year Old Patients With Asthma
NCT02680561COMPLETEDPHASE1
20 participants
INTERVENTIONAL
Huntington Beach, United States +2 more
Started: Apr 1, 2016
ROTAHALER Device Optimization Study
NCT01890863COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Randwick, Australia
Started: Aug 5, 2013
Showing 20 of 190 total trials