Tiotropium
Treatment for Asthma
Typical Dosage: 2.5 mcg (2 puffs) once daily
Effectiveness
75%
Safety Score
65%
Clinical Trials
53
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
2.5 mcg (2 puffs) once daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
500(Treat 500 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$5,400
Monitoring:$550
Side Effect Mgmt:$50
Total Annual:$6,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
0.02
Outcome-Based Costs
Cost per Responder
$9,231
Cost per Remission
$24,000
Comparison vs ICS/LABA combination
Cost Difference
+$4,475/year
More expensive
QALY Difference
+0.02 QALYs
Better outcomes
Dominance
No dominance
Tiotropium Outcomes
for Asthma
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+65%
Remission Rate
+25%
Common Side Effects
Dry mouth
+15%
Upper respiratory tract infection
+8%
Cough
+5%
Urinary retention
+0.5%
Sources:
Active Clinical Trials
1 active trial recruiting for Tiotropium in Asthma
Evaluating the Impact of Single Dose Tiotropium on Allergen-induced Early Asthmatic Response
NCT06679465NOT YET RECRUITINGPHASE4
10 participants
INTERVENTIONAL
Saskatoon, Canada
Started: Jan 1, 2025
Completed Clinical Trials
17 completed trials for Tiotropium in Asthma
Specific Use-Result of Spiriva Respimat® in Asthmatics
NCT03188120COMPLETED
193 participants
OBSERVATIONAL
Tokyo, Japan
Started: Jul 4, 2017
A Study to Evaluate Efficacy and Safety of Tiotropium in Children 6 to 11 Years Old With Moderate Asthma
NCT01383499COMPLETEDPHASE2
101 participants
INTERVENTIONAL
Bochum, Germany +23 more
Started: Aug 1, 2011
Specific Use-result Surveillance of Spiriva Respimat in Asthmatics
NCT02489981COMPLETED
359 participants
OBSERVATIONAL
Belo Horizonte, Brazil
Started: Jun 1, 2015
Efficacy and Safety of 3 Doses of Tiotropium Compared to Placebo in Adolescents (12 to 17 Yrs) With Moderate Asthma
NCT01122680COMPLETEDPHASE2
105 participants
INTERVENTIONAL
Denver, United States +18 more
Started: May 1, 2010
Characteristics of Pts Initiating Spiriva Respimat in Asthma
NCT03692676COMPLETED
116K participants
OBSERVATIONAL
Ingelheim, Germany
Started: Mar 5, 2019
Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo in 1 to 5 Year Old Patients With Persistent Asthma
NCT01634113COMPLETEDPHASE2
102 participants
INTERVENTIONAL
Columbia, United States +32 more
Started: Jul 1, 2012
Regular Use Tiotropium and Tolerance to Bronchoprotection in Mild Asthma
NCT05113615COMPLETEDPHASE4
12 participants
INTERVENTIONAL
Saskatoon, Canada
Started: Dec 13, 2021
Blacks and Exacerbations on Long Acting Beta Agonists (LABA) vs. Tiotropium (BELT)
NCT01290874COMPLETEDPHASE3
1.07K participants
INTERVENTIONAL
Jacksonville, United States +12 more
Started: Mar 30, 2011
Evaluation of Tiotropium 2.5 and 5 µg Once Daily Delivered Via the Respimat Inhaler Compared to Placebo in Patient With Moderate to Severe Persistent Asthma
NCT01340209COMPLETEDPHASE3
285 participants
INTERVENTIONAL
Asahikawa, Hokkaido, Japan +54 more
Started: Apr 1, 2011
Efficacy and Safety of 2 Doses of Tiotropium Via Respimat in Adult Patients With Mild Persistent Asthma
NCT01316380COMPLETEDPHASE3
465 participants
INTERVENTIONAL
Capital Federal, Argentina +61 more
Started: Mar 1, 2011
An Efficacy and Safety Evaluation of Tiotropium add-on Therapy in Patients With Severe Persistent Asthma
NCT00365560COMPLETEDPHASE2
115 participants
INTERVENTIONAL
Aalborg, Denmark +15 more
Started: Aug 1, 2006
Efficacy and Safety of 2 Doses of Tiotropium Respimat Compared to Placebo in Adolescents With Severe Persistent Asthma
NCT01277523COMPLETEDPHASE3
392 participants
INTERVENTIONAL
Stockton, United States +68 more
Started: Jan 1, 2011
Efficacy and Safety of 2 Doses of Tiotropium Respimat® Compared to Placebo in Children With Severe Persistent Asthma
NCT01634152COMPLETEDPHASE3
401 participants
INTERVENTIONAL
Rolling Hills Estates, United States +93 more
Started: Jul 1, 2012
Multiple Ascending Dose Study of TRN-157 in Stable Mild and Moderate Asthmatics
NCT02382510COMPLETEDPHASE2
59 participants
INTERVENTIONAL
Costa Mesa, United States +6 more
Started: Apr 1, 2015
Randomised, Double- Blind, Cross-over Efficacy and Safety Comparison of Three Different Doses of Tiotropium Administered Once Daily Versus Placebo in Patients With Moderate Persistent Asthma.
NCT01233284COMPLETEDPHASE2
149 participants
INTERVENTIONAL
Hallein, Austria +18 more
Started: Nov 1, 2010
Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC)
NCT00565266COMPLETEDPHASE3
210 participants
INTERVENTIONAL
San Diego, United States +9 more
Started: May 1, 2008
Duration of Long Acting Muscarinic Antagonist (LAMA) Bronchoprotection Against Methacholine Challenge
NCT02622243COMPLETEDPHASE4
13 participants
INTERVENTIONAL
Saskatoon, Canada
Started: Nov 1, 2015
Showing 20 of 53 total trials