Lamotrigine
Treatment for Bipolar Disorder
Typical Dosage: 100-400mg daily
Effectiveness
80%
Safety Score
60%
Clinical Trials
65
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
100-400mg daily
Time to Effect
8-12 weeks (after titration)
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$800
Side Effect Mgmt:$100
Total Annual:$1,100
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$40,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$2,200
Cost per Remission
$3,666.7
Comparison vs Lithium
Cost Difference
$-200/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$450
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$600/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$80/year
Prior auth, claims
Rx Price
$200/year
Potential OTC Price
$50/year
Estimated if OTC available
Early Treatment Benefit
+0.20 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWLamotrigine Outcomes
for Bipolar Disorder
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+50%
Remission Rate
+30%
Common Side Effects
Headache
+25%
Nausea
+15%
Dizziness
+17%
Rash (benign)
+10%
Stevens-Johnson Syndrome (SJS)/TEN
+0.1%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
19 completed trials for Lamotrigine in Bipolar Disorder
A Clinical Evaluation Of BW430C (Lamotrigine) In Bipolar I Disorder- Long-term Extension Of Study SCA104779 (NCT00550407) -
NCT00566020COMPLETEDPHASE3
92 participants
INTERVENTIONAL
Aichi, Japan +51 more
Started: May 1, 2008
Pregnant Women Taking Lamictal for Bipolar Disorder
NCT01996293COMPLETED
30 participants
OBSERVATIONAL
Chicago, United States
Started: Sep 1, 2013
Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
NCT02081287COMPLETEDPHASE1
8 participants
INTERVENTIONAL
San Diego, United States
Started: May 1, 2014
Lamotrigine Monotherapy in Pediatric Bipolar Disorder
NCT00176228COMPLETEDPHASE2
48 participants
INTERVENTIONAL
Chicago, United States
Started: Feb 1, 2004
Lamictal Bipolar Observational Study
NCT00460226COMPLETED
238 participants
OBSERVATIONAL
Started: Mar 1, 2007
An Evaluation Of BW430C (Lamotrigine) Versus Placebo In The Prevention Of Mood Episodes In Bipolar I Disorder Patients
NCT00550407COMPLETEDPHASE3
215 participants
INTERVENTIONAL
Aichi, Japan +59 more
Started: Nov 1, 2007
Pharmacokinetics, Safety and Tolerability of Repeat Dosing Lamotrigine in Healthy Chinese Subjects
NCT02513654COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Shanghai, China
Started: Sep 6, 2015
An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder
NCT00360126COMPLETEDPHASE4
11 participants
INTERVENTIONAL
Greenwich, Australia +2 more
Started: Oct 1, 2005
Lamictal as Add-on Treatment for Bipolar I Disorder in Pediatric Patients
NCT00723450COMPLETEDPHASE3
301 participants
INTERVENTIONAL
Dothan, United States +45 more
Started: Jul 1, 2008
Lamictal As Add on Treatment in Mixed States of Bipolar Disorder
NCT00223509COMPLETEDPHASE4
28 participants
INTERVENTIONAL
San Antonio, United States +1 more
Started: Aug 1, 2005
Bipolar Study in Adults at Least 18 Years of Age
NCT00067938COMPLETEDPHASE4
1.2K participants
INTERVENTIONAL
Albertville, United States +307 more
Started: Aug 1, 2003
Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder
NCT01864551COMPLETEDPHASE4
60 participants
INTERVENTIONAL
Taipei, Taiwan
Started: Aug 1, 2008
A Study To Investigate The Antidepressant Effect Of Lamotrigine In Patients With Bipolar Disorder Using Lithium
NCT00224510COMPLETEDPHASE3
120 participants
INTERVENTIONAL
Alkmaar, Netherlands +30 more
Started: Aug 1, 2002
A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode
NCT00277212COMPLETEDPHASE4
1.17K participants
INTERVENTIONAL
Birmingham, United States +65 more
Started: Dec 1, 2005
Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder
NCT00181844COMPLETEDPHASE4
51 participants
INTERVENTIONAL
Cambridge, United States
Started: Jan 1, 2005
Lamotrigine Phase III Study in Bipolar I Disorder
NCT01602510COMPLETEDPHASE3
265 participants
INTERVENTIONAL
Guangzhou, China +20 more
Started: Aug 1, 2012
Bipolar Disorder Study for Men and Women
NCT00056277COMPLETEDPHASE3
150 participants
INTERVENTIONAL
Beverly Hills, United States +19 more
Started: Feb 27, 2003
Lamotrigine for Symptoms of Geriatric Bipolar Depression
NCT00621842COMPLETEDPHASE3
57 participants
INTERVENTIONAL
White Plains, United States +4 more
Started: Jan 1, 2008
Special Drug Use Investigation for LAMICTAL Bipolar
NCT01428518COMPLETED
1.04K participants
OBSERVATIONAL
Started: Nov 1, 2011
Showing 20 of 65 total trials