Quetiapine
Treatment for Bipolar Disorder
Typical Dosage: 50-800mg daily
Effectiveness
88%
Safety Score
40%
Clinical Trials
120
Participants
40K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
50-800mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$600
Monitoring:$1,000
Side Effect Mgmt:$400
Total Annual:$2,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
0.6
Outcome-Based Costs
Cost per Responder
$3,076.9
Cost per Remission
$5,000
Comparison vs Olanzapine
Cost Difference
$-100/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Quetiapine Outcomes
for Bipolar Disorder
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+65%
Remission Rate
+40%
Common Side Effects
Sedation/Somnolence
+60%
Weight gain
+35%
Dry mouth
+20%
Dizziness
+15%
Metabolic changes (cholesterol, glucose)
+15%
Sources:
Active Clinical Trials
1 active trial recruiting for Quetiapine in Bipolar Disorder
Quality of Life, Safety and Compliance of Patients Using Monotherapy or Combinatorial Therapy With Quetiapine for Treatment of Schizophrenia or Bipolar Affective Disorder
NCT07858565RECRUITING
500 participants
OBSERVATIONAL
Sarajevo, Bosnia and Herzegovina
Started: Oct 30, 2025
Completed Clinical Trials
15 completed trials for Quetiapine in Bipolar Disorder
Phase III/Seroquel SR Bipolar Depression Monotherapy - US
NCT00422214COMPLETEDPHASE3
400 participants
INTERVENTIONAL
Birmingham, United States +53 more
Started: Dec 1, 2006
Pharmacokinetics of Quetiapine Across Pregnancy and Postpartum
NCT02978534COMPLETED
4 participants
OBSERVATIONAL
Chicago, United States
Started: Mar 1, 2016
Phase 3 /Seroquel SR Acute Mania Monotherapy - US
NCT00422123COMPLETEDPHASE3
447 participants
INTERVENTIONAL
Phoenix, United States +50 more
Started: Jan 1, 2007
Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders
NCT00252226COMPLETEDPHASE3
100 participants
INTERVENTIONAL
Ottawa, Canada
Started: Jun 1, 2004
Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder
NCT01195363COMPLETEDPHASE4
28 participants
INTERVENTIONAL
San Antonio, United States
Started: Apr 1, 2007
Effect of Quetiapine on Sleep Architecture in Bipolar Depression and Major Depressive Disorder
NCT00616889COMPLETED
15 participants
OBSERVATIONAL
Kingston, Canada
Started: May 1, 2006
Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder
NCT00181883COMPLETEDPHASE4
30 participants
INTERVENTIONAL
Started: Feb 1, 2005
Quetiapine Fumarate Bipolar Maintenance Monotherapy
NCT00314184COMPLETEDPHASE3
1.25K participants
INTERVENTIONAL
Cerritos, United States +94 more
Started: Mar 1, 2005
Effects of Quetiapine on Ultrastructural Hippocampal and Neurochemical Changes in Patients With Bipolar Disorder: Searching for Antidepressant and Mood Stabilising Neurophysiology
NCT01552837COMPLETEDNA
33 participants
INTERVENTIONAL
Aachen, Germany
Started: Dec 1, 2007
Efficacy of Quetiapine XR Versus Placebo as Concomitant Treatment to Mood Stabilizers in the Control of Subsyndromal Symptoms of Bipolar Disorder
NCT01197846COMPLETEDPHASE3
28 participants
INTERVENTIONAL
Barcelona, Spain +9 more
Started: Sep 1, 2010
Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Children & Adolescents With Bipolar I Mania
NCT00090311COMPLETEDPHASE3
220 participants
INTERVENTIONAL
Scottsdale, United States +31 more
Started: Jul 1, 2004
Controlled Study of the Use of Quetiapine Fumarate in the Treatment of Patients With Bipolar Depression
NCT00083954COMPLETEDPHASE3
530 participants
INTERVENTIONAL
Birmingham, United States +35 more
Started: Jun 1, 2004
Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms
NCT00277667COMPLETEDPHASE3
40 participants
INTERVENTIONAL
Cincinnati, United States
Started: Feb 1, 2004
A Survey on Quetiapine Extended-release Tablets in Patients With Depression in Bipolar Disorder
NCT03403790COMPLETED
369 participants
OBSERVATIONAL
Aichi, Japan +46 more
Started: Jan 15, 2018
Comparative Effectiveness Study for Bipolar Disorder
NCT01331304COMPLETEDPHASE4
482 participants
INTERVENTIONAL
Birmingham, United States +10 more
Started: Sep 1, 2010
Showing 20 of 124 total trials