DFDA

Valproate (Divalproex)

Treatment for Bipolar Disorder

Typical Dosage: 750-2500mg daily

Effectiveness
82%
Safety Score
35%
Clinical Trials
120
Participants
40K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
35
DangerousModerateSafe
Treatment Details
Dosage Range
750-2500mg daily
Time to Effect
1-3 weeks
Treatment Duration
lifetime
Evidence Quality
HIGH
Number Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$300
Monitoring:$1,000
Side Effect Mgmt:$300
Total Annual:$1,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$45,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$2,461.5
Cost per Remission
$4,000
Comparison vs Lithium
Cost Difference
+$200/year
More expensive
QALY Difference
-0.05 QALYs
Worse outcomes
Dominance
No dominance
Valproate (Divalproex) Outcomes

for Bipolar Disorder

Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+65%
Remission Rate
+40%
Common Side Effects
Nausea/vomiting
+25%
Weight gain
+30%
Tremor
+15%
Hair loss
+15%
Liver dysfunction
+7%
Teratogenicity
+7%

Sources:

nih.gov
nih.gov
bmj.com

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
16 completed trials for Valproate (Divalproex) in Bipolar Disorder

Gulf Evaluation of VAlproate (Depakine Chrono) in maNia Study

NCT00477373COMPLETEDPHASE4
View Study
70 participants
INTERVENTIONAL
Bahrain, Bahrain +3 more
Started: Dec 1, 2006

Drug Treatment for Alcoholics With Bipolar Disorder

NCT00000439COMPLETEDPHASE2
View Study
72 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Oct 1, 2000

Depakote ER in Bipolar Depression

NCT00186186COMPLETEDPHASE4
View Study
28 participants
INTERVENTIONAL
Stanford, United States
Started: Jan 1, 2004

VALID : VAlproate Versus LIthium in Bipolar Disorders

NCT00264173COMPLETEDPHASE4
View Study
270 participants
INTERVENTIONAL
Started: Feb 1, 2004

Risperidone and Divalproex Sodium With MRI Assessment in Pediatric Bipolar

NCT00176202COMPLETEDPHASE3
View Study
65 participants
INTERVENTIONAL
Chicago, United States +2 more
Started: Apr 1, 2003

Depakote-ER for Depressive and Bipolar Depression

NCT00226343COMPLETEDPHASE4
View Study
25 participants
INTERVENTIONAL
Started: Aug 1, 2003

Lithium Versus Divalproex for Treating Pediatric Bipolar Disorder

NCT00221429COMPLETEDPHASE3
View Study
153 participants
INTERVENTIONAL
Cincinnati, United States
Started: Mar 1, 2001

Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression

NCT00194116COMPLETEDPHASE3
View Study
54 participants
INTERVENTIONAL
Cleveland, United States
Started: Sep 1, 2004

An Inpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder

NCT00060905COMPLETEDPHASE3
View Study
370 participants
INTERVENTIONAL
Cerritos, United States +17 more
Started: Jan 1, 2003

Naturalistic Study, Comparison of Divalproex Extended Release (ER) and Quetiapine for Adults With Acute Mania or Mixed Episodes

NCT00397020COMPLETEDPHASE4
View Study
30 participants
INTERVENTIONAL
San Diego, United States
Started: Dec 1, 2006

Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder

NCT00194129COMPLETEDPHASE3
View Study
31 participants
INTERVENTIONAL
Cleveland, United States
Started: Nov 1, 1997

Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder

NCT00199966COMPLETEDPHASE4
View Study
30 participants
INTERVENTIONAL
Milwaukee, United States
Started: Dec 1, 2003

A Study for the Treatment of Mania Associated With Bipolar I Disorder in Children and Adolescents

NCT00195780COMPLETEDPHASE3
View Study
227 participants
INTERVENTIONAL
San Diego, United States +28 more
Started: Feb 1, 2005

Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling

NCT00221975COMPLETEDPHASE3
View Study
98 participants
INTERVENTIONAL
Cleveland, United States
Started: Jul 1, 2002

Evaluate the Safety of Depakote Extended Release Tablets in the Treatment of Mania Associated With Bipolar Disorder in Children and Adolescents

NCT00195767COMPLETEDPHASE3
View Study
150 participants
INTERVENTIONAL
North Chicago, United States
Started: Jul 1, 2004

Decision-Making in Bipolar Disorder

NCT01463111COMPLETEDNA
View Study
37 participants
INTERVENTIONAL
Atlanta, United States
Started: May 1, 2011
Showing 20 of 120 total trials