Lomustine
Treatment for Brain And Central Nervous System Cancer
Typical Dosage: 100-130 mg/m2 orally every 6 weeks
Effectiveness
45%
Safety Score
25%
Clinical Trials
40
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
100-130 mg/m2 orally every 6 weeks
Time to Effect
1-3 months
Treatment Duration
6-12 months
Evidence Quality
MODERATENumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15,000
Monitoring:$5,000
Side Effect Mgmt:$3,000
Total Annual:$23,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEQALYs Gained
0.03
Outcome-Based Costs
Cost per Responder
$153,333
Comparison vs Best Supportive Care
Cost Difference
+$23,000/year
More expensive
QALY Difference
+0.03 QALYs
Better outcomes
Dominance
No dominance
Lomustine Outcomes
for Brain And Central Nervous System Cancer
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+15%
Remission Rate
+1%
Common Side Effects
Myelosuppression (Thrombocytopenia, Leukopenia)
+70%
Nausea/Vomiting
+60%
Fatigue
+35%
Pulmonary fibrosis
+7%
Hepatotoxicity
+15%
Active Clinical Trials
1 active trial recruiting for Lomustine in Brain And Central Nervous System Cancer
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
NCT00887146ACTIVE NOT RECRUITINGPHASE3
305 participants
INTERVENTIONAL
Birmingham, United States +290 more
Started: Sep 1, 2009
Completed Clinical Trials
13 completed trials for Lomustine in Brain And Central Nervous System Cancer
Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma
NCT00006024COMPLETEDPHASE1
32 participants
INTERVENTIONAL
Birmingham, United States +234 more
Started: Nov 1, 2000
Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma
NCT00052455COMPLETEDPHASE3
500 participants
INTERVENTIONAL
London, United Kingdom
Started: Oct 1, 2002
Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma
NCT00002840COMPLETEDPHASE3
350 participants
INTERVENTIONAL
Vienna (Wien), Austria +39 more
Started: Aug 1, 1996
Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma
NCT00003375COMPLETEDPHASE2, PHASE3
370 participants
INTERVENTIONAL
Started: Oct 1, 1998
Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma
NCT00002569COMPLETEDPHASE3
299 participants
INTERVENTIONAL
Mobile, United States +94 more
Started: Jul 1, 1994
Combination Chemotherapy in Treating Children With Progressive Brain Tumors
NCT00002944COMPLETEDPHASE3
428 participants
INTERVENTIONAL
Mobile, United States +203 more
Started: Apr 1, 1997
Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma
NCT00002806COMPLETEDPHASE2
43 participants
INTERVENTIONAL
Scottsdale, United States +16 more
Started: Jul 1, 1996
Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas
NCT00004259COMPLETEDPHASE3
230 participants
INTERVENTIONAL
Mobile, United States +91 more
Started: Jun 1, 2000
Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma
NCT00058370COMPLETEDNA
6 participants
INTERVENTIONAL
New York, United States +1 more
Started: Feb 1, 2003
Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
NCT00303810COMPLETEDNA
567 participants
INTERVENTIONAL
Hamburg, Germany
Started: Jan 1, 2001
Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma
NCT00003101COMPLETEDPHASE2
60 participants
INTERVENTIONAL
Birmingham, United States +6 more
Started: Aug 1, 1997
Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain Tumour
NCT00503204COMPLETEDPHASE1
20 participants
INTERVENTIONAL
Boston, United States +1 more
Started: Sep 1, 2007
Temozolomide, Thalidomide, and Lomustine (TTL) in Melanoma Patients
NCT00527657COMPLETEDPHASE1
17 participants
INTERVENTIONAL
Houston, United States
Started: Feb 9, 2006
Showing 20 of 40 total trials