Carpal Tunnel Release Surgery
Treatment for Carpal Tunnel Syndrome
Typical Dosage: Surgical procedure
Effectiveness
92%
Safety Score
60%
Clinical Trials
85
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Surgical procedure
Time to Effect
Immediate relief of nocturnal symptoms, full recovery 3-6 months
Treatment Duration
One-time procedure, recovery period of weeks to months
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$500
Side Effect Mgmt:$400
Total Annual:$7,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$7,778
Cost per Remission
$8,235
Comparison vs Wrist Splinting
Cost Difference
+$6,800/year
More expensive
QALY Difference
+0.40 QALYs
Better outcomes
Dominance
No dominance
Active Clinical Trials
8 active trials recruiting for Carpal Tunnel Release Surgery in Carpal Tunnel Syndrome
Finnish Carpal Tunnel Surgery Study
NCT07614425RECRUITINGNA
180 participants
INTERVENTIONAL
Helsinki, Finland +1 more
Started: Jun 11, 2026
Changes in Sleep, Fatigue, Kinesiophobia, and Upper Extremity Function After Carpal Tunnel Release
NCT07806071NOT YET RECRUITING
100 participants
OBSERVATIONAL
Started: Sep 1, 2026
Carpal Tunnel Release Efficacy Trial
NCT06934187NOT YET RECRUITINGNA
96 participants
INTERVENTIONAL
Kuopio, Finland
Started: Jan 1, 2026
Evaluation by Clinical and Hand Ultrasound in Carpal Tunnel Syndrome
NCT07134361RECRUITING
106 participants
OBSERVATIONAL
São Paulo, Brazil
Started: Jun 25, 2025
Electrophysiological and Functional Recovery After Carpal Tunnel Release
NCT07803939NOT YET RECRUITINGNA
100 participants
INTERVENTIONAL
Started: Sep 1, 2026
Ultrasound-Guided Curved Needle Thread Carpal Tunnel Release: Efficacy and Safety of a Single-Center, Single-Arm Clinical Trial
NCT06440070RECRUITINGNA
69 participants
INTERVENTIONAL
Guangzhou, China
Started: Jan 1, 2024
Open vs. Ultrasound-Guided Carpal Tunnel Release
NCT07814547RECRUITING
200 participants
OBSERVATIONAL
Salzburg, Austria +1 more
Started: Jun 1, 2026
MeDe Study: Comparing Median Nerve Decompression at the Carpal Tunnel Alone Versus Median Nerve Decompression at Both the Carpal Tunnel and Lacertus Fibrosis in Adults With Carpal Tunnel Syndrome
NCT07594821RECRUITINGNA
110 participants
INTERVENTIONAL
Rotterdam, Netherlands +1 more
Started: May 6, 2026
Completed Clinical Trials
9 completed trials for Carpal Tunnel Release Surgery in Carpal Tunnel Syndrome
Minimal Invasive Carpal Tunnel Release With the Novel Device
NCT05067205COMPLETEDNA
41 participants
INTERVENTIONAL
Kaohsiung City, Taiwan
Started: Sep 8, 2021
Post-operative Mobilization for Carpal Tunnel Syndrome
NCT00435149COMPLETEDNA
100 participants
INTERVENTIONAL
Nashville, United States
Started: Dec 1, 2006
Very Early Outcomes in Endoscopic Versus Open Carpal Tunnel Release
NCT07364604COMPLETED
113 participants
OBSERVATIONAL
Palo Alto, United States
Started: Mar 1, 2022
Comparison of Long-term Outcomes Following Endoscopic or Open Surgery for Carpal Tunnel Syndrome
NCT01887145COMPLETEDNA
124 participants
INTERVENTIONAL
Started: Sep 1, 2013
Patient Outcomes With Endoscopic Versus Open Carpal Tunnel Release
NCT00880295COMPLETEDNA
38 participants
INTERVENTIONAL
Hershey, United States
Started: Mar 23, 2009
Comparative Outcomes of Endoscopic and Open Carpal Tunnel Release with Neurotrophic Supplementation in Severe Carpal Tunnel Syndrome
NCT06902831COMPLETED
497 participants
OBSERVATIONAL
Bari, Italy
Started: Jun 1, 2022
Ultrasound Guided - Incisionless Threaded Carpal Tunnel Release
NCT04101955COMPLETEDNA
12 participants
INTERVENTIONAL
Rochester, United States
Started: Jul 1, 2020
A Pilot Study to Evaluate the Effectiveness of Ultrasound Guided Looped Thread Carpal Tunnel Release
NCT03476486COMPLETEDPHASE2
20 participants
INTERVENTIONAL
Started: May 20, 2016
Pain in Carpal Tunnel Release Wide-awake Local Anesthesia With no Tourniquet vs Local Anesthesia With Tourniquet
NCT05747846COMPLETEDNA
82 participants
INTERVENTIONAL
Buenos Aires, Argentina
Started: Dec 15, 2020
Showing 20 of 99 total trials