Radiation Therapy (EBRT + Brachytherapy)
Treatment for Cervical Cancer
Typical Dosage: EBRT 45-50 Gy, Brachytherapy 20-30 Gy
Effectiveness
80%
Safety Score
25%
Clinical Trials
101
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
EBRT 45-50 Gy, Brachytherapy 20-30 Gy
Time to Effect
During and shortly after treatment
Treatment Duration
5-7 weeks
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$5,000
Side Effect Mgmt:$3,000
Total Annual:$45,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
5.5
Outcome-Based Costs
Cost per Responder
$56,250
Cost per Remission
$75,000
Comparison vs Radical Hysterectomy
Cost Difference
$0/year
Same cost
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Radiation Therapy (EBRT + Brachytherapy) Outcomes
for Cervical Cancer
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Remission Rate
+60%
Common Side Effects
Fatigue
+75%
Diarrhea/Proctitis
+60%
Cystitis
+40%
Vaginal stenosis/dryness
+70%
Bowel obstruction (late)
+8%
Sources:
Active Clinical Trials
11 active trials recruiting for Radiation Therapy (EBRT + Brachytherapy) in Cervical Cancer
Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix
NCT03256916ACTIVE NOT RECRUITINGPHASE3
348 participants
INTERVENTIONAL
Mumbai, India
Started: Jan 16, 2018
Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study
NCT05857631RECRUITINGNA
90 participants
INTERVENTIONAL
Navi Mumbai, India +1 more
Started: May 29, 2023
A Study of Nimotuzumab Plus Concurrent Chemoradiotherapy Sequential Maintenance Treatment for Cervical Carcinoma
NCT06333821NOT YET RECRUITINGPHASE3
460 participants
INTERVENTIONAL
Started: Apr 1, 2024
PROTECT: On-line Adaptive Proton Therapy for Cervical Cancer
NCT05406856RECRUITINGNA
30 participants
INTERVENTIONAL
Leiden, Netherlands +1 more
Started: May 2, 2022
Study of Chemoradiotherapy With Envafolimab For The Treatment of Locally Advanced Cervical Cancer
NCT05799469NOT YET RECRUITINGPHASE2
36 participants
INTERVENTIONAL
Chongqing, China
Started: May 1, 2023
A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01
NCT05570422NOT YET RECRUITINGPHASE1
70 participants
INTERVENTIONAL
Chandigarh, India +4 more
Started: Dec 1, 2025
A Study of Chemoradiotherapy With SHR-1316 For Treatment of Locally Advanced Cervical Cancer
NCT06237257ACTIVE NOT RECRUITINGPHASE2
56 participants
INTERVENTIONAL
Shanghai, China
Started: Mar 20, 2024
Study Of Cadonilimab Combined With Radiotherapy In The Treatment of Locally Advanced Cervical Cancer
NCT05687851RECRUITINGPHASE2
33 participants
INTERVENTIONAL
Chongqing, China
Started: Dec 29, 2022
Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer
NCT06529809RECRUITINGPHASE1, PHASE2
50 participants
INTERVENTIONAL
St Louis, United States
Started: Feb 11, 2025
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)
NCT04221945ACTIVE NOT RECRUITINGPHASE3
1.06K participants
INTERVENTIONAL
Phoenix, United States +175 more
Started: May 12, 2020
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
NCT02466971ACTIVE NOT RECRUITINGPHASE3
450 participants
INTERVENTIONAL
Birmingham, United States +381 more
Started: May 10, 2016
Completed Clinical Trials
5 completed trials for Radiation Therapy (EBRT + Brachytherapy) in Cervical Cancer
Feasibility Study of the Xoft® Axxent® Electronic Brachytherapy System for the Treatment of Cervical Cancer
NCT01851772COMPLETEDNA
3 participants
INTERVENTIONAL
Oklahoma City, United States
Started: Nov 1, 2013
Bevacizumab, Radiation Therapy, and Cisplatin in Treating Patients With Previously Untreated Locally Advanced Cervical Cancer
NCT00369122COMPLETEDPHASE2
60 participants
INTERVENTIONAL
Burbank, United States +105 more
Started: Aug 11, 2006
A Randomised Controlled Trial Between Two Different HDR Brachytherapy Schedule in Locally Advanced Carcinoma of Uterine Cervix
NCT02765919COMPLETEDPHASE3
30 participants
INTERVENTIONAL
Dhaka, Bangladesh
Started: Jul 1, 2015
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
NCT00980954COMPLETEDPHASE3
236 participants
INTERVENTIONAL
Birmingham, United States +124 more
Started: Sep 1, 2009
Dose Optimization in 3D Pulsed Dose Rate Brachytherapy for Patients With Locally Advanced Cervical Cancer
NCT02880007COMPLETEDPHASE2
48 participants
INTERVENTIONAL
Besançon, France +8 more
Started: Jun 6, 2011
Showing 20 of 105 total trials