Doxycycline
Treatment for Chlamydia
Typical Dosage: 100 mg orally twice daily
Effectiveness
97%
Safety Score
70%
Clinical Trials
19
Participants
75K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
100 mg orally twice daily
Time to Effect
3-7 days
Treatment Duration
7 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$7
Monitoring:$75
Side Effect Mgmt:$5
Total Annual:$87
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$12,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$89.69
Cost per Remission
$89.69
Comparison vs Azithromycin
Cost Difference
$-3/year
Less expensive
QALY Difference
-0.00 QALYs
Worse outcomes
Dominance
No dominance
Doxycycline Outcomes
for Chlamydia
Efficacy Outcomes
Overall Effectiveness
+97%
Response Rate
+97%
Remission Rate
+97%
Common Side Effects
Photosensitivity
+10%
Nausea
+10%
Esophageal irritation
+5%
Diarrhea
+5%
Sources:
Active Clinical Trials
5 active trials recruiting for Doxycycline in Chlamydia
A Study of Doxycycline to Treat Chlamydial Infection
NCT05840159RECRUITINGPHASE4
664 participants
INTERVENTIONAL
Birmingham, United States +6 more
Started: Jan 19, 2024
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
NCT06188442RECRUITINGPHASE4
300 participants
INTERVENTIONAL
Shatin, Hong Kong
Started: Mar 29, 2025
Phase II Trial of First-line Doxycycline for Ocular Adnexal Marginal Zone Lymphoma Treatment
NCT01820910ACTIVE NOT RECRUITINGPHASE2
34 participants
INTERVENTIONAL
Messina, Italy +6 more
Started: Mar 1, 2013
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
NCT06738407NOT YET RECRUITINGPHASE4
760 participants
INTERVENTIONAL
Los Angeles, United States +11 more
Started: Jan 5, 2026
Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM
NCT06468462RECRUITINGPHASE4
2.9K participants
INTERVENTIONAL
Kisumu, Kenya +2 more
Started: Oct 29, 2025
Completed Clinical Trials
9 completed trials for Doxycycline in Chlamydia
Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities
NCT00980148COMPLETEDPHASE3
567 participants
INTERVENTIONAL
Birmingham, United States +1 more
Started: Dec 1, 2009
Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin
NCT01113931COMPLETEDPHASE3
495 participants
INTERVENTIONAL
Birmingham, United States +42 more
Started: Apr 1, 2010
Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM
NCT03608774COMPLETEDPHASE4
177 participants
INTERVENTIONAL
Boston, United States +1 more
Started: Jul 13, 2018
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
NCT03980223COMPLETEDPHASE4
641 participants
INTERVENTIONAL
San Francisco, United States +2 more
Started: Nov 26, 2019
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
NCT05216744COMPLETEDPHASE2
125 participants
INTERVENTIONAL
Haiphong, Vietnam
Started: Jul 15, 2021
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
NCT04050540COMPLETEDPHASE4
449 participants
INTERVENTIONAL
Kisumu, Kenya
Started: Feb 5, 2020
Microorganism in Overactive Bladder Patients
NCT00883818COMPLETEDPHASE4
84 participants
INTERVENTIONAL
Inchon, South Korea +2 more
Started: Jan 1, 2007
A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae
NCT01010295COMPLETEDPHASE2
54 participants
INTERVENTIONAL
Providencia, Santiago, Chile +5 more
Started: Sep 1, 2006
Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria
NCT00351273COMPLETEDPHASE3
42 participants
INTERVENTIONAL
Tampa, United States +2 more
Started: May 1, 2006