Doxycycline
Treatment for Chlamydial Infection
Typical Dosage: 100mg orally twice daily for 7 days
Effectiveness
97%
Safety Score
70%
Clinical Trials
17
Participants
1M
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
100mg orally twice daily for 7 days
Time to Effect
1 week for cure
Treatment Duration
7 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
1.03(Treat 1.03 patients to see 1 additional successful outcome)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$600
Side Effect Mgmt:$10
Total Annual:$625
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$25.77
Cost per Remission
$25.77
Comparison vs Azithromycin
Cost Difference
$0/year
Same cost
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$-9,777
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$45/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$15/year
Potential OTC Price
$7/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWDoxycycline Outcomes
for Chlamydial Infection
Efficacy Outcomes
Overall Effectiveness
+97%
Response Rate
+97%
Remission Rate
+97%
Common Side Effects
Nausea
+15%
Diarrhea
+10%
Photosensitivity
+5%
Esophageal irritation
+3%
Active Clinical Trials
4 active trials recruiting for Doxycycline in Chlamydial Infection
A Study of Doxycycline to Treat Chlamydial Infection
NCT05840159RECRUITINGPHASE4
664 participants
INTERVENTIONAL
Birmingham, United States +6 more
Started: Jan 19, 2024
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
NCT06738407NOT YET RECRUITINGPHASE4
760 participants
INTERVENTIONAL
Los Angeles, United States +11 more
Started: Nov 28, 2025
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
NCT06188442RECRUITINGPHASE4
300 participants
INTERVENTIONAL
Shatin, Hong Kong
Started: Mar 29, 2025
Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM
NCT06468462RECRUITINGPHASE4
2.9K participants
INTERVENTIONAL
Kisumu, Kenya +2 more
Started: Oct 29, 2025
Completed Clinical Trials
9 completed trials for Doxycycline in Chlamydial Infection
Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities
NCT00980148COMPLETEDPHASE3
567 participants
INTERVENTIONAL
Birmingham, United States +1 more
Started: Dec 1, 2009
Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM
NCT03608774COMPLETEDPHASE4
177 participants
INTERVENTIONAL
Boston, United States +1 more
Started: Jul 13, 2018
Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin
NCT01113931COMPLETEDPHASE3
495 participants
INTERVENTIONAL
Birmingham, United States +42 more
Started: Apr 1, 2010
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
NCT03980223COMPLETEDPHASE4
641 participants
INTERVENTIONAL
San Francisco, United States +2 more
Started: Nov 26, 2019
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
NCT05216744COMPLETEDPHASE2
125 participants
INTERVENTIONAL
Haiphong, Vietnam
Started: Jul 15, 2021
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
NCT04050540COMPLETEDPHASE4
449 participants
INTERVENTIONAL
Kisumu, Kenya
Started: Feb 5, 2020
Microorganism in Overactive Bladder Patients
NCT00883818COMPLETEDPHASE4
84 participants
INTERVENTIONAL
Inchon, South Korea +2 more
Started: Jan 1, 2007
A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae
NCT01010295COMPLETEDPHASE2
54 participants
INTERVENTIONAL
Providencia, Santiago, Chile +5 more
Started: Sep 1, 2006
Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria
NCT00351273COMPLETEDPHASE3
42 participants
INTERVENTIONAL
Tampa, United States +2 more
Started: May 1, 2006