Prednisone (Corticosteroid)
Treatment for Chronic Kidney Disease Due To Glomerulonephritis
Typical Dosage: 0.5-1 mg/kg/day (initial), tapered
Effectiveness
75%
Safety Score
50%
Clinical Trials
200
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
0.5-1 mg/kg/day (initial), tapered
Time to Effect
days-weeks for anti-inflammatory effects
Treatment Duration
3-6 months (induction), then taper
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$500
Side Effect Mgmt:$1,000
Total Annual:$1,550
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
1.2
Outcome-Based Costs
Cost per Responder
$2,214
Cost per Remission
$3,100
Comparison vs No immunosuppression
Cost Difference
+$1,550/year
More expensive
QALY Difference
+1.20 QALYs
Better outcomes
Dominance
No dominance
Prednisone (Corticosteroid) Outcomes
for Chronic Kidney Disease Due To Glomerulonephritis
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+70%
Remission Rate
+50%
Common Side Effects
Weight gain/fluid retention
+60%
Hyperglycemia/diabetes
+30%
Hypertension
+20%
Insomnia/mood changes
+15%
Osteoporosis (long-term)
+15%
Infections
+10%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov