Saline Nasal Irrigation
Treatment for Chronic Sinusitis
Typical Dosage: 1-2 rinses per day
Effectiveness
65%
Safety Score
95%
Clinical Trials
29
Participants
8K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
1-2 rinses per day
Time to Effect
immediate
Treatment Duration
lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$600
Side Effect Mgmt:$0
Total Annual:$800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$333
Cost per Remission
$4,000
Saline Nasal Irrigation Outcomes
for Chronic Sinusitis
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+60%
Remission Rate
+5%
Common Side Effects
Nasal dryness
+2%
Nasal irritation
+1%
Sources:
Active Clinical Trials
2 active trials recruiting for Saline Nasal Irrigation in Chronic Sinusitis
Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
NCT05427695RECRUITINGPHASE2
60 participants
INTERVENTIONAL
Chicago, United States
Started: Feb 5, 2025
Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
NCT07151313NOT YET RECRUITINGNA
30 participants
INTERVENTIONAL
Cairo, Egypt
Started: Sep 15, 2025
Completed Clinical Trials
8 completed trials for Saline Nasal Irrigation in Chronic Sinusitis
Gulf War Illness Nasal Irrigation Study
NCT01700725COMPLETEDPHASE2
40 participants
INTERVENTIONAL
Madison, United States
Started: Oct 1, 2012
Adrenaline Solution Irrigation and Bleeding During Sinus Surgery
NCT04551703COMPLETEDPHASE1
60 participants
INTERVENTIONAL
Started: Jul 1, 2016
Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
NCT00465530COMPLETEDNA
40 participants
INTERVENTIONAL
Kansas City, United States +1 more
Started: Mar 1, 2007
Xylitol for Chronic Sinusitis
NCT03229551COMPLETEDPHASE2, PHASE3
1 participants
INTERVENTIONAL
New Orleans, United States
Started: Mar 1, 2018
Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis
NCT03705793COMPLETEDPHASE4
53 participants
INTERVENTIONAL
St Louis, United States +1 more
Started: Jan 1, 2019
Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis
NCT00335309COMPLETEDNA
50 participants
INTERVENTIONAL
Haifa, Israel
Started: Oct 1, 2005
Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS)
NCT04163978COMPLETEDPHASE2
56 participants
INTERVENTIONAL
Vancouver, Canada
Started: Oct 27, 2019
Saline Irrigation After Surgery in Patients With Chronic Sinusitis
NCT01575223COMPLETEDPHASE4
86 participants
INTERVENTIONAL
Calgary, Canada +3 more
Started: Mar 1, 2012
Showing 20 of 29 total trials