Verapamil
Treatment for Cluster Headache
Typical Dosage: 240-720 mg/day (extended-release)
Effectiveness
80%
Safety Score
70%
Clinical Trials
3
Participants
2.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
240-720 mg/day (extended-release)
Time to Effect
1-2 weeks
Treatment Duration
Months to years
Evidence Quality
HIGHNumber Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$360
Monitoring:$500
Side Effect Mgmt:$100
Total Annual:$960
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.3
Outcome-Based Costs
Cost per Responder
$1,477
Verapamil Outcomes
for Cluster Headache
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+65%
Common Side Effects
Constipation
+35%
Bradycardia
+15%
Hypotension
+8%
Fatigue
+7%
Dizziness
+7%
Sources:
Active Clinical Trials
1 active trial recruiting for Verapamil in Cluster Headache
Atrioventricular Block and Cluster Headache (SEVA)
NCT04406259ACTIVE NOT RECRUITINGPHASE4
60 participants
INTERVENTIONAL
Nice, France +1 more
Started: Nov 2, 2020
Completed Clinical Trials
1 completed trial for Verapamil in Cluster Headache
Cluster Headache Cortivazol Injection (CHCI)
NCT00804895COMPLETEDPHASE2, PHASE3
43 participants
INTERVENTIONAL
Paris, France
Started: Dec 1, 2008