Cognitive Behavioral Therapy (CBT)
Treatment for Cocaine Use Disorders
Typical Dosage: 60-90 minute sessions, 1-2 times per week
Effectiveness
75%
Safety Score
95%
Clinical Trials
15
Participants
12K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
60-90 minute sessions, 1-2 times per week
Time to Effect
2-3 months
Treatment Duration
12-24 weeks
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$400
Side Effect Mgmt:$0
Total Annual:$400
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$30,000/QALY
QALYs Gained
0.4
Outcome-Based Costs
Cost per Responder
$6,545
Cost per Remission
$10,286
Cognitive Behavioral Therapy (CBT) Outcomes
for Cocaine Use Disorders
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+55%
Remission Rate
+35%
Common Side Effects
Temporary discomfort during sessions
+5%
Emotional fatigue
+2%
Active Clinical Trials
5 active trials recruiting for Cognitive Behavioral Therapy (CBT) in Cocaine Use Disorders
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
NCT04843046RECRUITINGPHASE2
60 participants
INTERVENTIONAL
Houston, United States
Started: Aug 23, 2021
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
NCT07227948NOT YET RECRUITINGPHASE2
75 participants
INTERVENTIONAL
Houston, United States
Started: Nov 17, 2025
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
NCT05974202NOT YET RECRUITINGNA
30 participants
INTERVENTIONAL
New York, United States
Started: Dec 15, 2025
Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder
NCT05833529RECRUITINGNA
54 participants
INTERVENTIONAL
Fort-de-France, Martinique +1 more
Started: May 1, 2023
Treating Polysubstance Use Using a Novel Digital Technology
NCT05766631RECRUITINGPHASE3
240 participants
INTERVENTIONAL
Baltimore, United States +4 more
Started: Jul 26, 2023
Completed Clinical Trials
7 completed trials for Cognitive Behavioral Therapy (CBT) in Cocaine Use Disorders
Treatment Outcome in CBT for Cocaine Use
NCT03538548COMPLETEDNA
68 participants
INTERVENTIONAL
New York, United States
Started: Sep 30, 2014
Adaptive Treatment for Alcohol and Cocaine Dependence
NCT01032135COMPLETEDPHASE2, PHASE3
500 participants
INTERVENTIONAL
Philadelphia, United States +2 more
Started: Oct 1, 2008
The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)
NCT02174614COMPLETEDPHASE1
99 participants
INTERVENTIONAL
Bridgeport, United States +1 more
Started: Apr 1, 2015
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
NCT03662529COMPLETEDNA
35 participants
INTERVENTIONAL
Richmond, United States
Started: Jun 5, 2017
Quetiapine for the Reduction of Cocaine Use
NCT00631748COMPLETEDNA
60 participants
INTERVENTIONAL
Tacoma, United States
Started: Feb 1, 2008
PPARγ Agonist Treatment for Cocaine Dependence
NCT02774343COMPLETEDPHASE1, PHASE2
30 participants
INTERVENTIONAL
Houston, United States
Started: Aug 1, 2012
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
NCT01614106COMPLETEDNA
360 participants
INTERVENTIONAL
Miami, United States +1 more
Started: Jan 1, 2013