Contingency Management
Treatment for Cocaine Use Disorders
Typical Dosage: Daily/weekly urine drug screens with contingent rewards
Effectiveness
80%
Safety Score
95%
Clinical Trials
17
Participants
15K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
Daily/weekly urine drug screens with contingent rewards
Time to Effect
1-4 weeks
Treatment Duration
12-24 weeks
Evidence Quality
HIGHNumber Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$2,000
Side Effect Mgmt:$0
Total Annual:$4,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$15,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$6,154
Cost per Remission
$8,889
Comparison vs Standard Outpatient Therapy
Cost Difference
+$700/year
More expensive
QALY Difference
+0.15 QALYs
Better outcomes
Dominance
No dominance
Contingency Management Outcomes
for Cocaine Use Disorders
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+65%
Remission Rate
+45%
Common Side Effects
Anxiety related to performance
+5%
Mild stress
+3%
Active Clinical Trials
4 active trials recruiting for Contingency Management in Cocaine Use Disorders
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
NCT04927143RECRUITINGNA
600 participants
INTERVENTIONAL
Oconomowoc, United States +1 more
Started: Sep 15, 2021
Contingency Management for Drug Use: Does Age Matter?
NCT05521854RECRUITINGNA
175 participants
INTERVENTIONAL
Chicago, United States +1 more
Started: May 1, 2023
Smartphone Services for Stimulant Use Disorder
NCT07092059RECRUITINGNA
270 participants
INTERVENTIONAL
Boston, United States
Started: Jun 24, 2025
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
NCT06434818RECRUITINGPHASE2
300 participants
INTERVENTIONAL
Washington D.C., United States +2 more
Started: Jul 7, 2023
Completed Clinical Trials
13 completed trials for Contingency Management in Cocaine Use Disorders
Cocaine Use Reduction and Health
NCT03224546COMPLETEDNA
127 participants
INTERVENTIONAL
Lexington, United States
Started: Sep 15, 2017
PPARγ Agonist Treatment for Cocaine Dependence
NCT02774343COMPLETEDPHASE1, PHASE2
30 participants
INTERVENTIONAL
Houston, United States
Started: Aug 1, 2012
Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil
NCT03345394COMPLETEDNA
98 participants
INTERVENTIONAL
São Paulo, Brazil
Started: Dec 1, 2017
Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
NCT03799341COMPLETEDNA
63 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Nov 13, 2019
Targeting Anhedonia in Cocaine Use Disorder
NCT02773212COMPLETEDPHASE2
57 participants
INTERVENTIONAL
Chicago, United States
Started: Feb 1, 2017
Extending Long-term Outcomes Through an Adaptive Aftercare Intervention
NCT02143063COMPLETEDNA
274 participants
INTERVENTIONAL
Bridgeport, United States +3 more
Started: Aug 1, 2014
Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients
NCT00780702COMPLETEDPHASE1
41 participants
INTERVENTIONAL
Baltimore, United States
Started: May 8, 2008
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
NCT00158288COMPLETEDPHASE2
140 participants
INTERVENTIONAL
West Haven, United States
Started: Mar 1, 1997
RCT of an Integrative Intervention for Non-Treatment-Seeking Meth Users
NCT01926184COMPLETEDNA
110 participants
INTERVENTIONAL
San Francisco, United States
Started: Jan 1, 2013
Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment
NCT01376570COMPLETEDNA
242 participants
INTERVENTIONAL
The Bronx, United States +2 more
Started: Jun 1, 2012
Cannabidiol and Cocaine Craving/Dependence
NCT02559167COMPLETEDPHASE2
79 participants
INTERVENTIONAL
Montreal, Canada
Started: Jul 1, 2016
Smoking-Cessation and Stimulant Treatment (S-CAST)
NCT01077024COMPLETEDPHASE3
538 participants
INTERVENTIONAL
Tucson, United States +11 more
Started: Feb 1, 2010
The Therapeutic Workplace Initiation Study
NCT00249470COMPLETEDNA
117 participants
INTERVENTIONAL
Baltimore, United States
Started: Apr 1, 2003