DFDA

Disulfiram

Treatment for Cocaine Use Disorders

Typical Dosage: 125-500mg daily

Effectiveness
55%
Safety Score
55%
Clinical Trials
40
Participants
3K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
125-500mg daily
Time to Effect
1-2 weeks
Treatment Duration
6-12 months
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
100(Treat 100 patients to see 1 additional serious adverse event)
Confidence Score
65%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$800
Monitoring:$800
Side Effect Mgmt:$100
Total Annual:$1,700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
ICER
$100,000/QALY
QALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$3,778
Cost per Remission
$6,800
Disulfiram Outcomes

for Cocaine Use Disorders

Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+45%
Remission Rate
+25%
Common Side Effects
Headache
+15%
Fatigue/drowsiness
+10%
Metallic or garlic taste
+10%
Hepatotoxicity (elevated liver enzymes)
+3%

Sources:

cochrane.org
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov