Topiramate
Treatment for Cocaine Use Disorders
Typical Dosage: 50-300mg daily, titrated
Effectiveness
60%
Safety Score
58%
Clinical Trials
1
Participants
2.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
50-300mg daily, titrated
Time to Effect
2-4 weeks
Treatment Duration
3-6 months
Evidence Quality
MODERATENumber Needed to Treat (NNT)
9(Treat 9 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
100(Treat 100 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$400
Side Effect Mgmt:$200
Total Annual:$1,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$120,000/QALY
QALYs Gained
0.18
Outcome-Based Costs
Cost per Responder
$2,000
Cost per Remission
$4,000
Topiramate Outcomes
for Cocaine Use Disorders
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+50%
Remission Rate
+25%
Common Side Effects
Paresthesia (tingling)
+25%
Cognitive slowing/difficulty with concentration
+15%
Nausea
+12%
Weight loss
+12%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for Topiramate in Cocaine Use Disorders
Topiramate-Phentermine Combinations for Cocaine Dependence
NCT02239913COMPLETEDPHASE1
38 participants
INTERVENTIONAL
Lexington, United States
Started: Sep 1, 2014