Ketoconazole
Treatment for Cushings Syndrome
Typical Dosage: 200-1200 mg/day, divided doses
Effectiveness
60%
Safety Score
60%
Clinical Trials
4
Participants
2K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
200-1200 mg/day, divided doses
Time to Effect
2-4 weeks
Treatment Duration
lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$2,000
Monitoring:$1,500
Side Effect Mgmt:$500
Total Annual:$4,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$75,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$6,667
Cost per Remission
$6,667
Ketoconazole Outcomes
for Cushings Syndrome
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+60%
Remission Rate
+60%
Common Side Effects
Hepatotoxicity (elevated LFTs)
+15%
Nausea/Vomiting
+12%
Gynecomastia (men)
+12%
Hypogonadism
+8%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
3 completed trials for Ketoconazole in Cushings Syndrome
Treatment for Endogenous Cushing's Syndrome
NCT01838551COMPLETEDPHASE3
94 participants
INTERVENTIONAL
Los Angeles, United States +41 more
Started: Aug 1, 2014
A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.
NCT03277690COMPLETEDPHASE3
84 participants
INTERVENTIONAL
Los Angeles, United States +44 more
Started: Sep 26, 2017
Open-label Treatment in Cushing's Syndrome
NCT03621280COMPLETEDPHASE3
51 participants
INTERVENTIONAL
Fort Lauderdale, United States +29 more
Started: Jan 7, 2019