Mirtazapine
Treatment for Depression
Typical Dosage: 15-45mg daily
Effectiveness
75%
Safety Score
60%
Clinical Trials
67
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
15-45mg daily
Time to Effect
1-2 weeks (for sleep/appetite), 2-4 weeks (for mood)
Treatment Duration
Acute: 6-12 weeks; Continuation: 4-9 months; Maintenance: 1-2+ years
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
18(Treat 18 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$150
Monitoring:$1,000
Side Effect Mgmt:$150
Total Annual:$1,300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$30,000/QALY
QALYs Gained
0.28
Outcome-Based Costs
Cost per Responder
$2,167
Cost per Remission
$3,421
Mirtazapine Outcomes
for Depression
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+38%
Common Side Effects
Sedation/Drowsiness
+40%
Weight gain
+25%
Increased appetite
+25%
Dry mouth
+15%
Sources:
Active Clinical Trials
2 active trials recruiting for Mirtazapine in Depression
Trial of Mirtazapine for Depression in IBD
NCT06309472RECRUITINGPHASE2
76 participants
INTERVENTIONAL
London, United Kingdom +3 more
Started: May 1, 2024
Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ
NCT03935685ACTIVE NOT RECRUITINGPHASE2
120 participants
INTERVENTIONAL
Orange, United States
Started: Feb 26, 2019
Completed Clinical Trials
15 completed trials for Mirtazapine in Depression
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
NCT01949571COMPLETEDPHASE2
64 participants
INTERVENTIONAL
Mexico City, Mexico
Started: Jan 1, 2007
Mirtazapine Reduces ICD Shocks in ICD Patients With Depression and Anxiety
NCT00960830COMPLETEDNA
40 participants
INTERVENTIONAL
San Nicolás, Argentina
Started: Apr 1, 2007
LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression
NCT01601002COMPLETEDPHASE4
19 participants
INTERVENTIONAL
London, Canada
Started: Jun 1, 2012
PET Neuroimaging of [11C]Mirtazapine
NCT00288782COMPLETEDPHASE4
24 participants
INTERVENTIONAL
Risskov, Denmark
Started: Feb 1, 2006
Mirtazapine for Treating Cocaine Dependent Individuals Who Also Suffer From Depression
NCT00249444COMPLETEDPHASE2
86 participants
INTERVENTIONAL
New York, United States
Started: May 1, 2006
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
NCT00322309COMPLETEDPHASE2
24 participants
INTERVENTIONAL
Boston, United States
Started: Sep 1, 2005
Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy
NCT00150839COMPLETEDPHASE4
80 participants
INTERVENTIONAL
Erlangen, Germany
Started: Mar 1, 2006
The Measurement-based Care in Patients With Depressive Disorder: A Randomized Controlled Trial
NCT02191124COMPLETEDPHASE4
164 participants
INTERVENTIONAL
Beijing, China
Started: Jun 1, 2011
Short-term Metabolic Effects of Mirtazapine in Healthy Subjects
NCT00878540COMPLETEDPHASE1
12 participants
INTERVENTIONAL
Munich, Germany
Started: Sep 1, 2008
Efficacy of Mirtazapine in Major Depressive Disorder With Insomnia
NCT05978219COMPLETEDPHASE4
135 participants
INTERVENTIONAL
Dhaka, Bangladesh
Started: May 25, 2023
Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.
NCT02185131COMPLETEDPHASE2
16 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Sep 1, 2013
Effectiveness Study of Mirtazapine Combined With Paroxetine in Major Depressive Patients Without Early Improvement
NCT01458626COMPLETEDPHASE4
525 participants
INTERVENTIONAL
Beijing, China
Started: Nov 14, 2012
Pilot Study to Evaluate Individualized Choice of Antidepressants in Patients With Cancer
NCT01725048COMPLETEDEARLY_PHASE1
21 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Jan 1, 2011
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
NCT02646449COMPLETEDPHASE2
11 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Jun 1, 2015
Strategic Use of New Generation Antidepressants for Depression
NCT01109693COMPLETEDPHASE4
2.01K participants
INTERVENTIONAL
Nagoya, Japan +1 more
Started: Dec 1, 2010
Showing 20 of 68 total trials