Sertraline (SSRI)
Treatment for Depression
Typical Dosage: 50-200mg daily
Effectiveness
76%
Safety Score
60%
Clinical Trials
81
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
50-200mg daily
Time to Effect
2-4 weeks
Treatment Duration
Acute: 6-12 weeks; Continuation: 4-9 months; Maintenance: 1-2+ years
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
18(Treat 18 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$1,000
Side Effect Mgmt:$150
Total Annual:$1,350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$35,000/QALY
QALYs Gained
0.3
Outcome-Based Costs
Cost per Responder
$2,250
Cost per Remission
$3,857
Sertraline (SSRI) Outcomes
for Depression
Efficacy Outcomes
Overall Effectiveness
+76%
Response Rate
+60%
Remission Rate
+35%
Common Side Effects
Nausea
+25%
Diarrhea
+20%
Sexual dysfunction
+50%
Insomnia/Somnolence
+15%
Headache
+18%
Active Clinical Trials
3 active trials recruiting for Sertraline (SSRI) in Depression
Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)
NCT07011693NOT YET RECRUITINGPHASE4
400 participants
INTERVENTIONAL
Chongqing, China
Started: Jun 20, 2025
Pattern Separation in Major Depressive Disorder
NCT07139834NOT YET RECRUITINGPHASE1
30 participants
INTERVENTIONAL
New York, United States
Started: Jan 1, 2026
NMDA Modulation in Major Depressive Disorder
NCT04637620RECRUITINGPHASE2
90 participants
INTERVENTIONAL
Taichung, Taiwan
Started: Jun 1, 2017
Completed Clinical Trials
7 completed trials for Sertraline (SSRI) in Depression
A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women
NCT04094870COMPLETEDPHASE4
80 participants
INTERVENTIONAL
Lusaka, Zambia +1 more
Started: Oct 30, 2019
Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in Depression
NCT00157547COMPLETEDPHASE4
95 participants
INTERVENTIONAL
Started: Apr 1, 2003
Effect of Lactobacillus Plantarum 299v Supplementation on Major Depression Treatment
NCT02469545COMPLETEDPHASE2
60 participants
INTERVENTIONAL
Bialystok, Poland
Started: Jun 1, 2014
NMDA Modulation in Major Depressive Disorder in Late- Life
NCT03414931COMPLETEDPHASE2
136 participants
INTERVENTIONAL
Kaohsiung City, Taiwan +1 more
Started: Jan 1, 2016
Imaging Antidepressant vs. Cognitive Behavior Therapy Effects on Unipolar Depression
NCT00787501COMPLETEDPHASE1
98 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Jun 1, 2008
Cellular Aging and Neurobiology of Depression Study
NCT00285935COMPLETEDNA
228 participants
INTERVENTIONAL
San Francisco, United States
Started: Dec 16, 2010
Methylphenidate for Depressed Cancer Patients Receiving Palliative Care
NCT00129467COMPLETEDNA
47 participants
INTERVENTIONAL
Portland, United States
Started: Feb 1, 2005
Showing 20 of 82 total trials