Glimepiride (Sulfonylurea)
Treatment for Diabetes Mellitus Type 2
Typical Dosage: 1-8 mg daily
Effectiveness
82%
Safety Score
60%
Clinical Trials
61
Participants
400K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
1-8 mg daily
Time to Effect
Days to 1-2 weeks
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
35(Treat 35 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$450
Side Effect Mgmt:$100
Total Annual:$625
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$801.28
Cost per Remission
$20,833.33
Comparison vs Metformin
Cost Difference
+$110/year
More expensive
QALY Difference
-0.05 QALYs
Worse outcomes
Dominance
No dominance
Glimepiride (Sulfonylurea) Outcomes
for Diabetes Mellitus Type 2
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+78%
Remission Rate
+3%
Common Side Effects
Hypoglycemia
+12%
Weight gain
+3%
Nausea/Diarrhea
+3%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
18 completed trials for Glimepiride (Sulfonylurea) in Diabetes Mellitus Type 2
CANagliflozin Treatment And Trial Analysis-Sulfonylurea (CANTATA-SU) SGLT2 Add-on to Metformin Versus Glimepiride
NCT00968812COMPLETEDPHASE3
1.45K participants
INTERVENTIONAL
Calera, United States +137 more
Started: Sep 1, 2009
A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Sulfonylurea in Type 2 Diabetic Patients
NCT01242215COMPLETEDPHASE3
243 participants
INTERVENTIONAL
Chugoku, Japan +6 more
Started: Sep 17, 2010
Study to Compare Sitagliptin Versus Sulfonylurea Treatment During Ramadan Fasting in Patients With Type 2 Diabetes (MK-0431-262)
NCT01340768COMPLETEDPHASE3
870 participants
INTERVENTIONAL
Started: Jun 22, 2010
Efficacy and Safety Study of MP-513 in Combination With Sulfonylurea in Patients With Type 2 Diabetes
NCT00974090COMPLETEDPHASE3
194 participants
INTERVENTIONAL
Sapporo, Japan
Started: Sep 1, 2009
Dietary Impacts on Glucose-lowering Effects of Sitagliptin in Type 2 Diabetes
NCT02312063COMPLETEDPHASE4
48 participants
INTERVENTIONAL
Osaka, Japan +1 more
Started: Feb 1, 2015
Efficacy and Safety of Alogliptin Used in Combination With Sulfonylurea in Participants With Type 2 Diabetes in Japan
NCT01318083COMPLETEDPHASE2, PHASE3
312 participants
INTERVENTIONAL
Started: Aug 1, 2008
How Improvement in Control of Diabetes Influences the Production of a Hormone Produced in the Gut Which Improves the Release and Action of Insulin.
NCT00747383COMPLETEDNA
74 participants
INTERVENTIONAL
Bournemouth, United Kingdom
Started: Sep 1, 2008
Study of How Dulaglutide Compares to Placebo in Participants With Type 2 Diabetes Who Are Also on Sulfonylurea Therapy (AWARD-8)
NCT01769378COMPLETEDPHASE3
300 participants
INTERVENTIONAL
Chino, United States +30 more
Started: Jan 1, 2013
RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes
NCT00379769COMPLETEDPHASE3
4.45K participants
INTERVENTIONAL
Miranda, Australia +445 more
Started: Apr 1, 2001
Optimal Oral Hypoglycaemic Agents (OHA) for Combination With Insulin Glargine (Sulfonylurea vs. Metformin)
NCT00708578COMPLETEDPHASE4
99 participants
INTERVENTIONAL
Seoul, South Korea
Started: May 1, 2008
Comparing the Renal Effect of Dipeptidyl-peptidase 4 Inhibitors and Sulfonylureas
NCT03983551COMPLETEDPHASE4
101 participants
INTERVENTIONAL
Started: Mar 1, 2016
The Effect of Vildagliptin Based Treatment Versus Sulfonylurea on Glycemic Variability, Oxidative Stress, GLP-1, and Endothelial Function in Patients With Type 2 Diabetes
NCT01404676COMPLETEDPHASE4
34 participants
INTERVENTIONAL
Seoul, South Korea
Started: Jun 1, 2010
A Study to Test MK-0941 in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-0941-017)
NCT00792935COMPLETEDPHASE2
143 participants
INTERVENTIONAL
Started: Jan 1, 2009
Insulin Glargine (Lantus) vs Sulfonylurea (SU) for BETA Cell Function (BETA Study)
NCT00562172COMPLETEDPHASE4
75 participants
INTERVENTIONAL
Seoul, South Korea
Started: Sep 1, 2007
An Observational Study of Type II Diabetics Treated With Dual Therapy With or Without Sitagliptin (Januvia®/Xelevia®, MK-0431-201)
NCT01357135COMPLETED
3.45K participants
OBSERVATIONAL
Started: Jul 15, 2009
Long-term Safety Study of Alogliptin Used in Combination With Sulfonylurea or Metformin in Participants With Type 2 Diabetes in Japan
NCT01318135COMPLETEDPHASE2, PHASE3
576 participants
INTERVENTIONAL
Started: Jan 1, 2009
A Study of Dulaglutide in Japanese Participants With Type 2 Diabetes Mellitus
NCT01584232COMPLETEDPHASE3
361 participants
INTERVENTIONAL
Aichi, Japan +14 more
Started: Apr 1, 2012
Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263)
NCT01131182COMPLETEDPHASE4
1.15K participants
INTERVENTIONAL
Started: Jun 13, 2010
Showing 20 of 61 total trials