Insulin (Basal)
Treatment for Diabetes Mellitus Type 2
Typical Dosage: 0.2-1.0 units/kg/day, individualized
Effectiveness
92%
Safety Score
55%
Clinical Trials
392
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
0.2-1.0 units/kg/day, individualized
Time to Effect
Immediate to hours
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$6,000
Monitoring:$1,000
Side Effect Mgmt:$200
Total Annual:$7,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POORICER
$180,000/QALY
QALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$8,181.82
Comparison vs Metformin
Cost Difference
+$6,685/year
More expensive
QALY Difference
+0.10 QALYs
Better outcomes
Dominance
No dominance
Insulin (Basal) Outcomes
for Diabetes Mellitus Type 2
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+88%
Common Side Effects
Hypoglycemia (mild-moderate)
+30%
Weight gain
+8%
Injection site reactions
+2%
Lipohypertrophy
+7%
Active Clinical Trials
1 active trial recruiting for Insulin (Basal) in Diabetes Mellitus Type 2
A Research Study to See How Well Weekly Insulin Icodec Maintains Blood Sugar Levels Compared to Daily Basal Insulins in Adults With Type 2 Diabetes
NCT07112339RECRUITINGPHASE4
586 participants
INTERVENTIONAL
Calgary, Canada +74 more
Started: Aug 15, 2025
Completed Clinical Trials
12 completed trials for Insulin (Basal) in Diabetes Mellitus Type 2
Efficacy and Safety of Insuman Basal/Comb/Rapid in Patients With Type 2 Diabetes
NCT01630369COMPLETEDPHASE4
552 participants
INTERVENTIONAL
Kyiv, Ukraine
Started: Feb 1, 2012
Afrezza® INHALE-1 Study in Pediatrics
NCT04974528COMPLETEDPHASE3
319 participants
INTERVENTIONAL
Los Angeles, United States +38 more
Started: Sep 29, 2021
Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM)
NCT00979628COMPLETEDPHASE4
375 participants
INTERVENTIONAL
Atlanta, United States +4 more
Started: Jan 1, 2010
Exenatide and Basal Insulins Use in the Real Setting: an Observational Study in Patients With Type 2 Diabetes
NCT01060059COMPLETED
888 participants
OBSERVATIONAL
Acquaviva delle Fonti, Italy +49 more
Started: Apr 1, 2010
A Study of Insulin Efsitora Alfa (LY3209590) Compared to Glargine in Adult Participants With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time (QWINT-1)
NCT05662332COMPLETEDPHASE3
795 participants
INTERVENTIONAL
Birmingham, United States +70 more
Started: Jan 14, 2023
Afrezza® Dosing Optimization Study
NCT04849845COMPLETEDPHASE4
20 participants
INTERVENTIONAL
Escondido, United States +1 more
Started: Apr 9, 2021
Preserving Beta-cell Function in Type 2 Diabetes With Exenatide and Insulin (PREVAIL)
NCT02194595COMPLETEDPHASE3
105 participants
INTERVENTIONAL
Toronto, Canada
Started: Sep 1, 2014
A Study of Basal Insulin Analog and Insulin Analog Mid Mixture in Chinese Participants With Type 2 Diabetes Mellitus
NCT03018938COMPLETEDPHASE4
814 participants
INTERVENTIONAL
Beijing, China +31 more
Started: Feb 6, 2017
A Digital Health Tool for Insulin Titration (DHIT) Individuals With Type 2 Diabetes: A Prospective Outcomes Study With a Retrospective Control Group
NCT03138447COMPLETEDNA
30 participants
INTERVENTIONAL
Towson, United States
Started: Mar 30, 2017
Efficacy and Safety of FIAsp in a Basal-bolus Regimen Versus Basal Insulin Therapy, Both in Combination With Metformin in Adult Subjects With Type 2 Diabetes
NCT01850615COMPLETEDPHASE3
323 participants
INTERVENTIONAL
Birmingham, United States +57 more
Started: Sep 23, 2013
The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South Asians
NCT03819790COMPLETEDPHASE4
119 participants
INTERVENTIONAL
Brampton, Canada +2 more
Started: Oct 2, 2018
Comparison of Thrice-Daily Premixed Human Insulin with Basal-Bolus Therapy Among Patients with Poorly Controlled Type 2 Diabetes Mellitus
NCT06855615COMPLETEDPHASE4
44 participants
INTERVENTIONAL
George Town, Malaysia
Started: Oct 1, 2020
Showing 20 of 394 total trials