Lifestyle Modifications (Diet & Exercise)
Treatment for Diabetes Mellitus Type 2
Typical Dosage: 30-60 minutes moderate-intensity exercise 5x/week, calorie-restricted balanced diet
Effectiveness
92%
Safety Score
95%
Clinical Trials
7
Participants
2M
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
30-60 minutes moderate-intensity exercise 5x/week, calorie-restricted balanced diet
Time to Effect
1-4 weeks for glucose, 3-6 months for significant weight loss/remission
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10000(Treat 10000 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$425
Side Effect Mgmt:$20
Total Annual:$445
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$-5,000/QALY
QALYs Gained
1.75
Outcome-Based Costs
Cost per Responder
$556.25
Cost per Remission
$1,112.5
Lifestyle Modifications (Diet & Exercise) Outcomes
for Diabetes Mellitus Type 2
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+80%
Remission Rate
+40%
Common Side Effects
Muscle soreness/injury
+7%
Hypoglycemia (if on medication and diet/exercise not adjusted)
+0.5%
Nutritional deficiencies (with poorly managed restrictive diets)
+0.1%
Active Clinical Trials
6 active trials recruiting for Lifestyle Modifications (Diet & Exercise) in Diabetes Mellitus Type 2
Student Pharmacist Non-Pharmacological Intervention on Type 2 Diabetes Management in Older Asian Adult Populations
NCT06861491NOT YET RECRUITINGNA
200 participants
INTERVENTIONAL
Started: Apr 1, 2025
A Feasibility Study of Optimal Non-Pharmacological Lifestyle Modifications in People With Type 2 Diabetes
NCT07262788RECRUITINGNA
24 participants
INTERVENTIONAL
Herlev, Denmark
Started: Sep 30, 2025
Precision Lifestyle Interventions Guided by Continuous Glucose Monitoring: Impact on Glycemic Outcomes in Type 2 Diabetes Mellitus
NCT06960512NOT YET RECRUITINGNA
200 participants
INTERVENTIONAL
Started: May 1, 2025
Effectiveness and Safety of Tirzepatide Among Participants With Obesity With or Without Type 2 Diabetes Mellitus (T2DM)
NCT07099742NOT YET RECRUITING
364 participants
OBSERVATIONAL
Comilla, Bangladesh +2 more
Started: Sep 1, 2025
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
NCT01047735ACTIVE NOT RECRUITINGNA
69 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Sep 1, 2009
EffectiVenEss of a Rehabilitation Treatment With Nordic Walking in obEse or oveRweight Patients
NCT05987410RECRUITINGNA
105 participants
INTERVENTIONAL
Milan, Italy
Started: Dec 1, 2023
Completed Clinical Trials
1 completed trial for Lifestyle Modifications (Diet & Exercise) in Diabetes Mellitus Type 2
Lifestyle Intervention and Its Effects on Inflammatory Cytokines and Oxidative Stress Markers in Diabetic Chronic Kidney Disease Patients: A Randomized Controlled Trial
NCT07119892COMPLETEDNA
60 participants
INTERVENTIONAL
Cairo, Egypt
Started: Mar 1, 2025