Loperamide
Treatment for Diarrheal Diseases
Typical Dosage: 4 mg initially, then 2 mg after each loose stool, max 8 mg/day
Effectiveness
80%
Safety Score
80%
Clinical Trials
6
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe
Treatment Details
Dosage Range
4 mg initially, then 2 mg after each loose stool, max 8 mg/day
Time to Effect
1 hour
Treatment Duration
1-2 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10
Monitoring:$800
Side Effect Mgmt:$0
Total Annual:$810
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$200/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$11.76
Loperamide Outcomes
for Diarrheal Diseases
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+85%
Common Side Effects
Constipation
+10%
Abdominal cramps
+5%
Nausea
+3%
Dizziness
+3%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
2 completed trials for Loperamide in Diarrheal Diseases
Calcium Aluminosilicate Anti-Diarrheal in Treating and Preventing Diarrhea in Patients With Metastatic Colorectal Cancer Receiving Irinotecan
NCT00748215COMPLETEDPHASE2
100 participants
INTERVENTIONAL
Portland, United States +1 more
Started: Feb 4, 2009
Study in Healthy Adults Challenged With Enterotoxigenic E. Coli, of the Safety, Tolerability and Anti-Diarrheal Activity of VENBETA6890, an Orally Administered, Human Monoclonal IgA
NCT06896136COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Baltimore, United States
Started: Feb 11, 2025