Hirschsprung's Disease Pull-through Procedure
Treatment for Digestive Congenital Anomalies
Effectiveness
90%
Safety Score
48%
Clinical Trials
7
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanideโ ๏ธ
Meth๐
Cigarettes๐ฌ
Chemoโข๏ธ
Alcohol๐บ
Morphine๐
Antibiotics๐
Tylenol๐
Exercise๐
Water๐ง
48
DangerousModerateSafe
Treatment Details
Time to Effect
Immediate surgical relief of obstruction, functional improvement over 3-6 months
Treatment Duration
Acute (surgical), 1-2 weeks hospitalization, long-term follow-up (years)
Evidence Quality
MODERATEConfidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$80,000
Side Effect Mgmt:$10,000
Total Annual:$90,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
68
Outcome-Based Costs
Cost per Responder
$100,556
Cost per Remission
$106,471
Hirschsprung's Disease Pull-through Procedure Outcomes
for Digestive Congenital Anomalies
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+85%
Common Side Effects
Hirschsprung-associated enterocolitis (HAEC)
+20%
Anastomotic stricture
+10%
Fecal incontinence/soiling
+20%
Constipation
+15%
Anastomotic leak
+3%
Sources:
Active Clinical Trials
3 active trials recruiting for Hirschsprung's Disease Pull-through Procedure in Digestive Congenital Anomalies
Long-term Qualitative and Quantitative Outcomes of Children With Hirschsprung's Disease and Anorectal Malformations
NCT05450991RECRUITING
1.2K participants
OBSERVATIONAL
Liverpool, United Kingdom
Started: Jan 25, 2022
Robot/Laparoscopic-Assisted Transanal Transection Duhamel Versus Modified Soave Pull-Through for TCA
NCT07343622NOT YET RECRUITINGNA
50 participants
INTERVENTIONAL
Zunyi, China
Started: Jan 30, 2026
Urinary and Sexual Symptoms in Patients With Hirschsprung Disease
NCT07742436NOT YET RECRUITING
556 participants
OBSERVATIONAL
Clermont-Ferrand, France +4 more
Started: Aug 1, 2026
Completed Clinical Trials
3 completed trials for Hirschsprung's Disease Pull-through Procedure in Digestive Congenital Anomalies
Minimally Invasive Surgical Intervention for Hirschsprung's Disease in Pediatric Patients
NCT06874686COMPLETED
1.05K participants
OBSERVATIONAL
Hanoi, Vietnam
Started: Jan 1, 2017
Minimally Invasive Surgical Intervention for Hirschsprung Disease
NCT06880666COMPLETEDNA
23 participants
INTERVENTIONAL
Hanoi, Vietnam
Started: Jan 1, 2020
Laparoscopic-Assisted Transanal Pull-Through for Hirschsprung Disease in Pediatric:Short and Intermediate Outcomes of Two Different Techniques
NCT07186647COMPLETEDPHASE4
40 participants
INTERVENTIONAL
Cairo, Egypt
Started: Sep 1, 2020