DFDA

Mesalazine (5-ASA)

Treatment for Diverticulitis

Typical Dosage: 1.2-4.8g daily in divided doses

Effectiveness
30%
Safety Score
75%
Clinical Trials
6
Participants
8K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
1.2-4.8g daily in divided doses
Time to Effect
Weeks to months
Treatment Duration
Months to years
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
30(Treat 30 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
25(Treat 25 patients to see 1 additional serious adverse event)
Confidence Score
50%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$9,000
Monitoring:$300
Side Effect Mgmt:$150
Total Annual:$9,450
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POOR
QALYs Gained
0.01
Outcome-Based Costs
Cost per Responder
$37,800
Comparison vs High-Fiber Diet
Cost Difference
+$9,400/year
More expensive
QALY Difference
-0.19 QALYs
Worse outcomes
Dominance
No dominance
Mesalazine (5-ASA) Outcomes

for Diverticulitis

Efficacy Outcomes
Overall Effectiveness
+30%
Response Rate
+25%
Common Side Effects
Headache
+15%
Nausea
+8%
Abdominal pain
+6%
Rash
+2%
Nephrotoxicity (rare)
+0.1%

Sources:

nih.gov
researchgate.net
researchgate.net

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
4 completed trials for Mesalazine (5-ASA) in Diverticulitis

Prevention of Recurrence of Diverticulitis

NCT00545740COMPLETEDPHASE3
View Study
590 participants
INTERVENTIONAL
Litchfield Park, United States +120 more
Started: Nov 28, 2007

Prevention of Recurrence of Diverticulitis

NCT00545103COMPLETEDPHASE3
View Study
592 participants
INTERVENTIONAL
Birmingham, United States +130 more
Started: Dec 6, 2007

Asacol Acute Diverticulitis(DIVA)Study

NCT00554099COMPLETEDPHASE2
View Study
117 participants
INTERVENTIONAL
Tucson, United States +35 more
Started: Nov 1, 2007

Evaluation of Efficacy of Mesalamine in the Long-term Prevention of Diverticulitis Flares

NCT01120340COMPLETEDPHASE3
View Study
105 participants
INTERVENTIONAL
Seriate, Italy +16 more
Started: Oct 1, 2005