Oral Antibiotics (e.g., Ciprofloxacin + Metronidazole)
Treatment for Diverticulitis
Typical Dosage: Ciprofloxacin 500mg BID + Metronidazole 500mg TID
Effectiveness
80%
Safety Score
70%
Clinical Trials
1
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Ciprofloxacin 500mg BID + Metronidazole 500mg TID
Time to Effect
1-2 days
Treatment Duration
7-10 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$250
Side Effect Mgmt:$75
Total Annual:$400
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POORICER
$150,000/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$444
Cost per Remission
$471
Comparison vs Conservative Management (for uncomplicated cases)
Cost Difference
+$200/year
More expensive
QALY Difference
-0.03 QALYs
Worse outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$270
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$50/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$75/year
Potential OTC Price
$25/year
Estimated if OTC available
Early Treatment Benefit
+0.00 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
HIGHMissed Diagnosis Risk
LOWOral Antibiotics (e.g., Ciprofloxacin + Metronidazole) Outcomes
for Diverticulitis
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+90%
Remission Rate
+85%
Common Side Effects
Diarrhea
+15%
Nausea
+8%
Metallic taste (Metronidazole)
+25%
Tendonitis (Ciprofloxacin, rare)
+0.5%
Clostridioides difficile infection
+2%
Sources:
Active Clinical Trials
1 active trial recruiting for Oral Antibiotics (e.g., Ciprofloxacin + Metronidazole) in Diverticulitis
Effectiveness and Safety of Outpatient Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics
NCT06517264ENROLLING BY INVITATIONNA
282 participants
INTERVENTIONAL
Murcia, Spain
Started: Nov 1, 2024