Methotrexate (Systemic)
Treatment for Ectopic Pregnancy
Typical Dosage: 50 mg/m^2 IM (single-dose) or 1 mg/kg IM alternating with folinic acid (multi-dose)
Effectiveness
90%
Safety Score
30%
Clinical Trials
2
Participants
12K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
50 mg/m^2 IM (single-dose) or 1 mg/kg IM alternating with folinic acid (multi-dose)
Time to Effect
2-4 weeks for hCG resolution
Treatment Duration
single dose or multi-dose over 8 days, monitoring for 2-4 weeks
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$1,000
Side Effect Mgmt:$300
Total Annual:$1,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.9
Outcome-Based Costs
Cost per Responder
$1,667
Cost per Remission
$1,667
Comparison vs Laparoscopic Salpingectomy
Cost Difference
$-7,000/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Methotrexate (Systemic) Outcomes
for Ectopic Pregnancy
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Abdominal pain/cramping
+50%
Nausea/vomiting
+15%
Fatigue
+15%
Transient liver enzyme elevation
+10%
Stomatitis
+3%
Active Clinical Trials
1 active trial recruiting for Methotrexate (Systemic) in Ectopic Pregnancy
Local vs Systemic Methotrexate in Management of Uterine Ectopic Pregnancy
NCT06554470RECRUITINGNA
34 participants
INTERVENTIONAL
Tanta, Egypt
Started: Aug 15, 2024
Completed Clinical Trials
1 completed trial for Methotrexate (Systemic) in Ectopic Pregnancy
The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy
NCT02714998COMPLETEDNA
131 participants
INTERVENTIONAL
Izmir, Turkey (Türkiye)
Started: Jan 1, 2013