DFDA

Methylprednisolone

Treatment for Encephalitis

Typical Dosage: 1g IV daily for 3-5 days

Effectiveness
85%
Safety Score
35%
Clinical Trials
8
Participants
3K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
35
DangerousModerateSafe
Treatment Details
Dosage Range
1g IV daily for 3-5 days
Time to Effect
3-7 days
Treatment Duration
3-5 days IV, then oral taper for weeks-months
Evidence Quality
HIGH
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$10,000
Side Effect Mgmt:$1,000
Total Annual:$11,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$30,000/QALY
QALYs Gained
7
Outcome-Based Costs
Cost per Responder
$18,667
Cost per Remission
$24,889
Methylprednisolone Outcomes

for Encephalitis

Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+60%
Remission Rate
+45%
Common Side Effects
Hyperglycemia
+40%
Insomnia
+15%
Increased infection risk
+10%

Sources:

houstonmethodist.org
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
3 active trials recruiting for Methylprednisolone in Encephalitis

The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

NCT04372615RECRUITINGPHASE2
View Study
116 participants
INTERVENTIONAL
Birmingham, United States +38 more
Started: Mar 30, 2022

IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2

NCT03194815RECRUITINGPHASE2
View Study
70 participants
INTERVENTIONAL
Cambridge, United Kingdom +9 more
Started: Nov 1, 2017

Adjunctive Doxycycline for Central Nervous System Tuberculosis

NCT06446245RECRUITINGPHASE2
View Study
200 participants
INTERVENTIONAL
Medan, Indonesia +4 more
Started: Aug 21, 2025
Completed Clinical Trials
2 completed trials for Methylprednisolone in Encephalitis

CPI Combination Therapy for Autoimmune Encephalitis

NCT03542279COMPLETEDNA
View Study
70 participants
INTERVENTIONAL
Beijing, China
Started: Nov 25, 2020

To Explore Cognitive Neural Mechanism of Autoimmune Encephalitis by Using Neuropsychological Tests and Multi-modal MRI

NCT03530462COMPLETED
View Study
22 participants
OBSERVATIONAL
Hangzhou, China
Started: Apr 7, 2017