Plasma Exchange (PLEX)

Treatment for Encephalitis

Typical Dosage: 1-1.5 plasma volumes exchanged per session

Effectiveness

80%

Safety Score

50%

Clinical Trials

Participants

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Treatment Details

Dosage Range

1-1.5 plasma volumes exchanged per session

Time to Effect

5-10 days

Treatment Duration

5-7 exchanges over 1-2 weeks

Evidence Quality

MODERATE

Number Needed to Treat (NNT)

4(Treat 4 patients to see 1 additional successful outcome)

Number Needed to Harm (NNH)

10(Treat 10 patients to see 1 additional serious adverse event)

Confidence Score

85%confidence in effectiveness data

Health Economics

Annual Cost of Care

Drug Cost:$0

Monitoring:$35,000

Side Effect Mgmt:$1,500

Total Annual:$36,500

Cost-Effectiveness Analysis

Cost-Effectiveness Rating

MODERATE

ICER

$110,000/QALY

QALYs Gained

Outcome-Based Costs

Cost per Responder

$60,833

Cost per Remission

$81,111

Plasma Exchange (PLEX) Outcomes

for Encephalitis

Efficacy Outcomes

Overall Effectiveness

+80%

Response Rate

+60%

Remission Rate

+45%

Common Side Effects

Hypotension

+15%

Citrate toxicity

+10%

Catheter-related infection

+2%

Sources:

researchgate.net

nih.gov

frontiersin.org

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials

1 active trial recruiting for Plasma Exchange (PLEX) in Encephalitis

Plasma Exchange in Pediatric Autoimmune Encephalitis

NCT07707739RECRUITINGNA

View Study

22 participants

INTERVENTIONAL

Shibīn al Kawm, Egypt

Started: Aug 1, 2026