Penicillin G
Treatment for Endocarditis
Typical Dosage: 12-24 million units/day IV
Effectiveness
92%
Safety Score
70%
Clinical Trials
6
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
12-24 million units/day IV
Time to Effect
2-5 days
Treatment Duration
2-6 weeks IV
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$100,000
Side Effect Mgmt:$1,000
Total Annual:$101,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
1.5
Outcome-Based Costs
Cost per Responder
$115,341
Cost per Remission
$123,780
Penicillin G Outcomes
for Endocarditis
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+88%
Remission Rate
+82%
Common Side Effects
Hypersensitivity reaction (rash, anaphylaxis)
+7%
Diarrhea
+3%
Nausea/Vomiting
+3%
Seizures (high doses, renal impairment)
+0.5%
Active Clinical Trials
2 active trials recruiting for Penicillin G in Endocarditis
Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.
NCT06423898RECRUITINGPHASE4
284 participants
INTERVENTIONAL
Alava, Spain +17 more
Started: Oct 9, 2024
Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis
NCT05398679RECRUITINGPHASE4
360 participants
INTERVENTIONAL
Seville, Spain +19 more
Started: Aug 17, 2022
Completed Clinical Trials
1 completed trial for Penicillin G in Endocarditis
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
NCT01431326COMPLETED
3.52K participants
OBSERVATIONAL
Anchorage, United States +51 more
Started: Nov 1, 2011