Dienogest
Treatment for Endometriosis
Typical Dosage: 2mg daily
Effectiveness
82%
Safety Score
60%
Clinical Trials
37
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
2mg daily
Time to Effect
1-3 months
Treatment Duration
Long-term (years)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$960
Monitoring:$500
Side Effect Mgmt:$100
Total Annual:$1,560
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$2,080
Cost per Remission
$3,467
Comparison vs Leuprolide
Cost Difference
$-5,000/year
Less expensive
QALY Difference
-0.05 QALYs
Worse outcomes
Dominance
No dominance
Dienogest Outcomes
for Endometriosis
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+75%
Remission Rate
+45%
Common Side Effects
Irregular bleeding/spotting
+30%
Headache
+12%
Breast discomfort
+8%
Depressed mood/mood changes
+7%
Acne
+7%
Sources:
Active Clinical Trials
3 active trials recruiting for Dienogest in Endometriosis
Clinical Study to Compare Efficacy and Safety of Indinol Forto® 200 mg Capsules and Visanne 2 mg Tablets in Treatment of Endometriosis
NCT07164183RECRUITINGPHASE3
290 participants
INTERVENTIONAL
Kazan', Russia +7 more
Started: Sep 11, 2025
Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy
NCT06414720RECRUITING
90 participants
OBSERVATIONAL
Udine, Italy
Started: Apr 22, 2024
Ultra-Safe Hormonal Strategy: Transdermal Estradiol Added to Progestins for Endometriosis
NCT07204093ACTIVE NOT RECRUITING
138 participants
OBSERVATIONAL
Milan, Italy
Started: Aug 11, 2025
Completed Clinical Trials
10 completed trials for Dienogest in Endometriosis
The Effect of Dienogest vs. Norethindrone Acetate Treatment in Endometriosis
NCT05476172COMPLETEDNA
70 participants
INTERVENTIONAL
Bursa, Turkey (Türkiye)
Started: Apr 1, 2021
Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue
NCT04374006COMPLETEDEARLY_PHASE1
120 participants
INTERVENTIONAL
Jakarta, Indonesia
Started: Nov 1, 2019
A Study to Learn More About Using Dienogest to Treat Endometriosis in Chinese Participants
NCT04495855COMPLETED
968 participants
OBSERVATIONAL
Multiple Locations, China
Started: Oct 28, 2020
Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients
NCT01822080COMPLETEDPHASE3
250 participants
INTERVENTIONAL
Guangzhou, China +25 more
Started: Mar 1, 2013
Visanne Study to Assess Safety in Adolescents
NCT01283724COMPLETEDPHASE2
111 participants
INTERVENTIONAL
Sankt Pölten, Austria +35 more
Started: Mar 1, 2011
Pretreatment With Dienogest in Women With Endometriosis Undergoing in Vitro-fertilization After a Previous Failed Cycle
NCT04306276COMPLETED
140 participants
OBSERVATIONAL
Genoa, Italy
Started: Jan 1, 2020
To Evaluate Effectiveness of Visanne in Improving Quality of Life in Asian Women With Endometriosis
NCT02425462COMPLETED
895 participants
OBSERVATIONAL
Multiple Locations, Indonesia +5 more
Started: Apr 28, 2015
The Effect of Dionegest Use on the Frequency of Fibromyalgia in Endometriosis
NCT05272930COMPLETED
61 participants
OBSERVATIONAL
Istanbul, Turkey (Türkiye)
Started: Jun 30, 2021
Regulatory Post Marketing Surveillance Study in Korea
NCT01788722COMPLETED
3.22K participants
OBSERVATIONAL
Multiple Locations, South Korea
Started: Jul 19, 2013
Daily Practice Treatment and Influence of Visanne on the Patient Assessment of Quality of Life
NCT01595724COMPLETED
3.01K participants
OBSERVATIONAL
Many Locations, Belarus +10 more
Started: May 1, 2012
Showing 20 of 40 total trials