Elagolix
Treatment for Endometriosis
Typical Dosage: 150mg daily or 200mg twice daily
Effectiveness
80%
Safety Score
55%
Clinical Trials
23
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
150mg daily or 200mg twice daily
Time to Effect
1-2 months
Treatment Duration
Up to 24 months (low dose), 6 months (high dose)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$13,000
Monitoring:$800
Side Effect Mgmt:$200
Total Annual:$14,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POORICER
$160,000/QALY
QALYs Gained
0.12
Outcome-Based Costs
Cost per Responder
$21,538
Cost per Remission
$40,000
Comparison vs Leuprolide
Cost Difference
+$1,000/year
More expensive
QALY Difference
+0.02 QALYs
Better outcomes
Dominance
No dominance
Elagolix Outcomes
for Endometriosis
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+65%
Remission Rate
+35%
Common Side Effects
Hot flashes
+35%
Headache
+18%
Nausea
+12%
Insomnia
+10%
Bone mineral density loss
+8%
Sources:
Active Clinical Trials
4 active trials recruiting for Elagolix in Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
NCT03746535RECRUITINGEARLY_PHASE1
40 participants
INTERVENTIONAL
New Haven, United States
Started: Jul 1, 2022
Comparison of Elagolix and OCPs in Reducing Endometriosis Associated Pelvic Pain
NCT07532876ENROLLING BY INVITATIONPHASE4
90 participants
INTERVENTIONAL
Rawalpindi, Pakistan
Started: May 1, 2026
Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain
NCT04333576ACTIVE NOT RECRUITINGPHASE3
800 participants
INTERVENTIONAL
Anniston, United States +178 more
Started: Aug 10, 2020
Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp
NCT06375811ACTIVE NOT RECRUITINGPHASE3
97 participants
INTERVENTIONAL
Aurora, United States +4 more
Started: Mar 16, 2024
Completed Clinical Trials
13 completed trials for Elagolix in Endometriosis
A Clinical Trial to Evaluate Efficacy and Safety of Elagolix Tablets in Women With Moderate or Severe Endometriosis-associated Pain
NCT06076486COMPLETEDPHASE3
202 participants
INTERVENTIONAL
Beijing, China
Started: Sep 14, 2023
Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain
NCT02143713COMPLETEDPHASE3
496 participants
INTERVENTIONAL
Started: May 27, 2014
Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain
NCT01760954COMPLETEDPHASE3
506 participants
INTERVENTIONAL
Started: Dec 28, 2012
A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain
NCT01931670COMPLETEDPHASE3
815 participants
INTERVENTIONAL
Started: Sep 9, 2013
A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain
NCT01620528COMPLETEDPHASE3
872 participants
INTERVENTIONAL
Started: May 22, 2012
An Open-label Study of the Effects of Elagolix in Adult Premenopausal Females
NCT01403038COMPLETEDPHASE1
216 participants
INTERVENTIONAL
Colorado Springs, United States +21 more
Started: Jun 1, 2011
An Efficacy and Safety Study of Elagolix (NBI-56418) in Women With Endometriosis
NCT00619866COMPLETEDPHASE2
155 participants
INTERVENTIONAL
Started: Feb 19, 2008
Efficacy and Safety Study of Elagolix in Women With Endometriosis
NCT00973973COMPLETEDPHASE2
137 participants
INTERVENTIONAL
Started: Oct 12, 2009
A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain
NCT03213457COMPLETEDPHASE3
681 participants
INTERVENTIONAL
Birmingham, United States +196 more
Started: Jul 7, 2017
Efficacy and Safety Study of Elagolix Versus Placebo or Leuprorelin Acetate in Endometriosis
NCT00797225COMPLETEDPHASE2
174 participants
INTERVENTIONAL
Started: Nov 26, 2008
Elagolix for Fertility Enhancement Clinical Trial
NCT04039204COMPLETEDPHASE2
10 participants
INTERVENTIONAL
Winston-Salem, United States
Started: Jan 15, 2022
Elagolix Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis
NCT00437658COMPLETEDPHASE2
252 participants
INTERVENTIONAL
Started: Dec 11, 2006
Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis
NCT04173169COMPLETEDPHASE3
103 participants
INTERVENTIONAL
Aurora, United States +4 more
Started: Mar 15, 2022
Showing 20 of 25 total trials