DFDA

Letrozole

Treatment for Endometriosis

Typical Dosage: 2.5mg daily

Effectiveness
88%
Safety Score
50%
Clinical Trials
6
Participants
1K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
2.5mg daily
Time to Effect
1-3 months
Treatment Duration
6-12 months (with add-back therapy)
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$800
Side Effect Mgmt:$300
Total Annual:$1,300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$30,000/QALY
QALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$1,625
Cost per Remission
$2,600
Letrozole Outcomes

for Endometriosis

Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+80%
Remission Rate
+50%
Common Side Effects
Hot flashes
+80%
Joint pain (arthralgia)
+40%
Fatigue
+25%
Headache
+15%
Bone mineral density loss
+15%

Sources:

nih.gov
researchgate.net
researchgate.net

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
2 active trials recruiting for Letrozole in Endometriosis

Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian Cystectomy

NCT05487092RECRUITINGNA
View Study
194 participants
INTERVENTIONAL
Hong Kong, Hong Kong +4 more
Started: Dec 1, 2022

Ovarian Hyperstimulation and Fibrin Clot Properties.

NCT04166825RECRUITINGNA
View Study
300 participants
INTERVENTIONAL
Krakow, Poland
Started: Nov 18, 2019
Completed Clinical Trials
4 completed trials for Letrozole in Endometriosis

Letrozole vs Danazol for Endometriosis-Related Pain: Randomized Trial

NCT07183787COMPLETEDPHASE2
View Study
60 participants
INTERVENTIONAL
Lahore, Pakistan
Started: Apr 10, 2019

Efficacy of Letrozole and CC Alone in an IUI Program in Cases With Surgically Treated Minimal to Mild Endometriosis

NCT01334762COMPLETEDNA
View Study
136 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: May 1, 2007

Letrozole in the Treatment of Severe and Recurrent Endometriosis

NCT00240942COMPLETEDPHASE2
View Study
40 participants
INTERVENTIONAL
Started: Oct 1, 2002

Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis

NCT04002141COMPLETEDPHASE2
View Study
60 participants
INTERVENTIONAL
San Francisco, United States
Started: Sep 17, 2019