Leuprolide
Treatment for Endometriosis
Typical Dosage: 3.75mg IM monthly
Effectiveness
78%
Safety Score
55%
Clinical Trials
28
Participants
8K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
3.75mg IM monthly
Time to Effect
1-2 months (after initial flare-up)
Treatment Duration
3-6 months (with add-back therapy)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$8,000
Monitoring:$1,000
Side Effect Mgmt:$200
Total Annual:$9,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$75,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$13,143
Cost per Remission
$26,286
Comparison vs Combined Oral Contraceptives
Cost Difference
+$7,000/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Leuprolide Outcomes
for Endometriosis
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+70%
Remission Rate
+35%
Common Side Effects
Hot flashes
+75%
Headache
+20%
Mood changes/depression
+15%
Vaginal dryness
+15%
Bone mineral density loss
+8%
Flare-up effect
+15%
Active Clinical Trials
3 active trials recruiting for Leuprolide in Endometriosis
Phase Ia Trial of HHK001 Compared With Enantone in Patients With Endometriosis
NCT07755956RECRUITINGPHASE1
30 participants
INTERVENTIONAL
Changsha, China
Started: Aug 31, 2026
A Phase Ia Trial Comparing the Pharmacokinetics/Pharmacodynamics, Safety, and Preliminary Efficacy of HHK001 and Enantone in Patients With Endometriosis
NCT07793162NOT YET RECRUITINGPHASE1
20 participants
INTERVENTIONAL
Started: Aug 31, 2026
A Clinical Study of KLH-2109 in Patients With Endometriosis
NCT07015268ACTIVE NOT RECRUITINGPHASE3
288 participants
INTERVENTIONAL
Multiple Locations, Japan
Started: Jun 9, 2025
Completed Clinical Trials
15 completed trials for Leuprolide in Endometriosis
Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With Endometriosis
NCT03931915COMPLETEDPHASE3
335 participants
INTERVENTIONAL
Aichi, Japan +40 more
Started: May 8, 2019
GnRH-a on Angiogenesis of Endometriosis
NCT06106932COMPLETEDNA
60 participants
INTERVENTIONAL
Patra, Greece +1 more
Started: Sep 1, 2015
A Study of Pharmacokinetic/Pharmacodynamic Profile of Orally Administered Leuprolide in Healthy Female Volunteers
NCT02807363COMPLETEDPHASE2
35 participants
INTERVENTIONAL
Québec, Canada
Started: Aug 23, 2017
A Study to Assess the Effectiveness and Safety of Different Doses of ASP1707 Compared to Placebo for Endometriosis Associated Pelvic Pain
NCT01767090COMPLETEDPHASE2
912 participants
INTERVENTIONAL
Brussels, Belgium +84 more
Started: Dec 4, 2012
Efficacy and Safety Study of Elagolix Versus Placebo or Leuprorelin Acetate in Endometriosis
NCT00797225COMPLETEDPHASE2
174 participants
INTERVENTIONAL
Started: Nov 26, 2008
Degarelix in the Treatment of Endometriosis Recurrence
NCT01712763COMPLETEDPHASE3
360 participants
INTERVENTIONAL
Tirana, Albania +2 more
Started: Nov 1, 2012
Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF
NCT00621179COMPLETEDPHASE4
37 participants
INTERVENTIONAL
Lone Tree, United States
Started: Mar 1, 2003
Late Phase II Clinical Study of KLH-2109 in Patients With Endometriosis
NCT02778919COMPLETEDPHASE2
INTERVENTIONAL
Multiple Locations, Japan
Started: May 9, 2016
Bay98-7196, Dose Finding / POC Study
NCT02203331COMPLETEDPHASE2
319 participants
INTERVENTIONAL
San Diego, United States +116 more
Started: Oct 16, 2014
GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles.
NCT01269125COMPLETEDNA
180 participants
INTERVENTIONAL
Ioannina, Greece
Started: May 1, 2004
Efficacy and Safety of TAK-385 in the Treatment of Endometriosis
NCT01458301COMPLETEDPHASE2
487 participants
INTERVENTIONAL
Nagoya, Japan +68 more
Started: Oct 1, 2011
A Long-term Extension Study of TAK-385 in the Treatment of Endometriosis
NCT01452685COMPLETEDPHASE2
397 participants
INTERVENTIONAL
Nagoya, Japan +68 more
Started: Mar 1, 2012
Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis
NCT02158845COMPLETEDPHASE4
44 participants
INTERVENTIONAL
Ribeirão Preto, Brazil
Started: Feb 1, 2010
Comparison of the Operation and Medical Treatment of Endometriosis and Adenomyosis
NCT03778359COMPLETED
5K participants
OBSERVATIONAL
Taipei County, Taiwan
Started: Jan 1, 2005
Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery
NCT06145438COMPLETEDPHASE3
80 participants
INTERVENTIONAL
Semarang, Indonesia
Started: Sep 4, 2023
Showing 20 of 30 total trials