Ethionamide / Prothionamide (as part of regimens)
Treatment for Extensively Drug Resistant Tuberculosis
Typical Dosage: 250-1000mg daily
Effectiveness
60%
Safety Score
45%
Clinical Trials
20
Participants
1.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe
Treatment Details
Dosage Range
250-1000mg daily
Time to Effect
3-6 months
Treatment Duration
18-24 months
Evidence Quality
LOWConfidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$250
Monitoring:$1,500
Side Effect Mgmt:$1,500
Total Annual:$3,250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$50,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$5,417
Cost per Remission
$5,417
Comparison vs Less effective older XDR-TB regimens
Cost Difference
$-500/year
Less expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
No dominance
Ethionamide / Prothionamide (as part of regimens) Outcomes
for Extensively Drug Resistant Tuberculosis
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+60%
Remission Rate
+60%
Common Side Effects
Gastrointestinal intolerance
+60%
Hepatotoxicity
+15%
Psychiatric disturbances (depression, psychosis)
+12%
Peripheral neuropathy
+15%
Hypothyroidism
+7%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov