Amitriptyline
Treatment for Fibromyalgia
Typical Dosage: 10-50mg daily
Effectiveness
60%
Safety Score
58%
Clinical Trials
10
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
10-50mg daily
Time to Effect
2-6 weeks
Treatment Duration
Long-term
Evidence Quality
MODERATENumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
4(Treat 4 patients to see 1 additional serious adverse event)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$180
Monitoring:$500
Side Effect Mgmt:$150
Total Annual:$830
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
0.03
Outcome-Based Costs
Cost per Responder
$2,371.43
Cost per Remission
$27,666.67
Amitriptyline Outcomes
for Fibromyalgia
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+35%
Remission Rate
+3%
Common Side Effects
Dry mouth
+50%
Sedation
+40%
Constipation
+25%
Dizziness
+20%
Weight gain
+15%
Sources:
Active Clinical Trials
1 active trial recruiting for Amitriptyline in Fibromyalgia
Effectiveness of AI-Guided Exercise and Pain Neuroscience Education for Fibromyalgia (FIBROIA)
NCT06672419NOT YET RECRUITINGNA
50 participants
INTERVENTIONAL
Concepción, Chile +1 more
Started: Feb 1, 2026
Completed Clinical Trials
6 completed trials for Amitriptyline in Fibromyalgia
Combining N-of-1 Trials to Assess Fibromyalgia Treatments
NCT00000428COMPLETEDPHASE4
58 participants
INTERVENTIONAL
Brockton, United States +6 more
Started: Sep 1, 2000
Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia
NCT00766350COMPLETEDPHASE4
90 participants
INTERVENTIONAL
Granada, Spain
Started: Nov 1, 2008
Newer Antidepressants in Combination With Pregabalin for Fibromyalgia Syndrome
NCT02451475COMPLETEDPHASE1, PHASE2
75 participants
INTERVENTIONAL
Started: Feb 1, 2013
Nabilone Versus Amitriptyline in Improving Quality of Sleep in Patients With Fibromyalgia
NCT00381199COMPLETEDNA
32 participants
INTERVENTIONAL
Montreal, Canada
Started: Apr 1, 2006
Growth Hormone as Add-on Treatment in Severe Fibromyalgia With Low IGF-1 Serum Levels (56 Characters)
NCT00497562COMPLETEDPHASE2
INTERVENTIONAL
Barcelona, Spain
Started: May 1, 2004
Improvement of the Health-related Quality of Life of Patients With Fibromyalgia Using Multidisciplinary Treatment
NCT01266733COMPLETEDPHASE2
153 participants
INTERVENTIONAL
Galdakao, Spain
Started: Feb 1, 2007