Duloxetine
Treatment for Fibromyalgia
Typical Dosage: 30-60mg daily
Effectiveness
65%
Safety Score
59%
Clinical Trials
32
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
59
DangerousModerateSafe
Treatment Details
Dosage Range
30-60mg daily
Time to Effect
1-4 weeks
Treatment Duration
Long-term
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$480
Monitoring:$500
Side Effect Mgmt:$150
Total Annual:$1,130
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$48,000/QALY
QALYs Gained
0.04
Outcome-Based Costs
Cost per Responder
$2,825
Cost per Remission
$22,600
Duloxetine Outcomes
for Fibromyalgia
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+40%
Remission Rate
+5%
Common Side Effects
Nausea
+30%
Dry mouth
+25%
Dizziness
+20%
Somnolence
+15%
Constipation
+15%
Sources:
Active Clinical Trials
1 active trial recruiting for Duloxetine in Fibromyalgia
Duloxetine Metabolism and Fibromyalgia
NCT06866444RECRUITING
100 participants
OBSERVATIONAL
Salt Lake City, United States
Started: May 1, 2025
Completed Clinical Trials
14 completed trials for Duloxetine in Fibromyalgia
An Extension Study of Duloxetine in Fibromyalgia (Extension of F1J-JE-HMGZ, NCT01552057)
NCT01621191COMPLETEDPHASE3
149 participants
INTERVENTIONAL
Miyagi, Japan
Started: Jun 1, 2012
Shugan Dingtong Decoction in the Treatment of Fibromyalgia
NCT05508516COMPLETEDEARLY_PHASE1
72 participants
INTERVENTIONAL
Beijing, China
Started: Sep 1, 2022
A Study of Duloxetine in Adolescents With Juvenile Primary Fibromyalgia Syndrome
NCT01237587COMPLETEDPHASE3
184 participants
INTERVENTIONAL
Phoenix, United States +32 more
Started: Mar 1, 2011
Comparative Efficacy of Duloxetine vs Escitalopram in Patients With Fibromyalgia
NCT03487211COMPLETEDPHASE2, PHASE3
200 participants
INTERVENTIONAL
Islamabad, Pakistan
Started: Apr 9, 2018
A Study of Duloxetine in the Treatment of Fibromyalgia
NCT00125892COMPLETEDPHASE3
320 participants
INTERVENTIONAL
Buenos Aires, Argentina +26 more
Started: Jul 1, 2005
A Study Comparing Duloxetine and Placebo in the Treatment of Fibromyalgia
NCT00673452COMPLETEDPHASE4
530 participants
INTERVENTIONAL
Phoenix, United States +45 more
Started: Jun 1, 2008
Study of Duloxetine Versus Placebo in the Treatment of Fibromyalgia Syndrome
NCT00190866COMPLETEDPHASE3
210 participants
INTERVENTIONAL
Peoria, United States +34 more
Started: Jun 1, 2005
A Study for Adult Patients With Fibromyalgia
NCT00965081COMPLETEDPHASE4
308 participants
INTERVENTIONAL
Guadalajara, Mexico +3 more
Started: Sep 1, 2009
A Study of Duloxetine in Fibromyalgia
NCT01552057COMPLETEDPHASE3
393 participants
INTERVENTIONAL
Miyagi, Japan
Started: Mar 1, 2012
Duloxetine Versus Placebo for Fibromyalgia
NCT00489073COMPLETEDPHASE3
345 participants
INTERVENTIONAL
Indianapolis, United States
Started: Nov 1, 2002
Duloxetine Versus Placebo in the Treatment of FMS
NCT00233025COMPLETEDPHASE3
320 participants
INTERVENTIONAL
Birmingham, United States +33 more
Started: Sep 1, 2005
Study to Assess Mechanisms in Peripheral Tissue Innervation for Fibromyalgia
NCT01127490COMPLETEDNA
25 participants
INTERVENTIONAL
Albany, United States
Started: May 5, 2010
Pilot, Opened, Randomized Clinical Trial to Assess the Efficacy of Duloxetine in the Treatment of Fibromialgy in Patients With Infection by HIV 1+
NCT00552682COMPLETEDPHASE3
10 participants
INTERVENTIONAL
Badalona, Spain
Started: Jan 1, 2007
The Effect of Transcutaneous Posterior Tibial Nerve Stimulation in Patients With Fibromyalgia
NCT05937711COMPLETEDNA
64 participants
INTERVENTIONAL
Giresun, Turkey (Türkiye) +1 more
Started: Nov 2, 2020
Showing 20 of 33 total trials