Milnacipran
Treatment for Fibromyalgia
Typical Dosage: 50-100mg daily
Effectiveness
63%
Safety Score
59%
Clinical Trials
28
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanideβ οΈ
Methπ
Cigarettesπ¬
Chemoβ’οΈ
AlcoholπΊ
Morphineπ
Antibioticsπ
Tylenolπ
Exerciseπ
Waterπ§
59
DangerousModerateSafe
Treatment Details
Dosage Range
50-100mg daily
Time to Effect
2-4 weeks
Treatment Duration
Long-term
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$900
Monitoring:$500
Side Effect Mgmt:$150
Total Annual:$1,550
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$65,000/QALY
QALYs Gained
0.035
Outcome-Based Costs
Cost per Responder
$4,428.57
Cost per Remission
$38,750
Milnacipran Outcomes
for Fibromyalgia
Efficacy Outcomes
Overall Effectiveness
+63%
Response Rate
+35%
Remission Rate
+4%
Common Side Effects
Nausea
+40%
Headache
+20%
Constipation
+15%
Dizziness
+15%
Insomnia
+15%
Hyperhidrosis (sweating)
+15%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
14 completed trials for Milnacipran in Fibromyalgia
Effects of Milnacipran on Widespread Mechanical and Thermal Hyperalgesia of Fibromyalgia Patients
NCT01294059COMPLETEDPHASE1
51 participants
INTERVENTIONAL
Gainesville, United States
Started: Nov 1, 2009
Study of Milnacipran in Patients With Inadequate Response to Duloxetine for the Treatment of Fibromyalgia
NCT01077375COMPLETEDPHASE4
107 participants
INTERVENTIONAL
Sacramento, United States +25 more
Started: Feb 1, 2010
Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia
NCT01014585COMPLETEDPHASE4
340 participants
INTERVENTIONAL
Birmingham, United States +57 more
Started: Nov 1, 2009
A Multicentre Trial to Determine the Efficacy and Safety of Milnacipran in the Treatment of Fibromyalgia Syndrome
NCT00436033COMPLETEDPHASE3
1.43K participants
INTERVENTIONAL
Pardubice, Czechia +12 more
Started: Feb 1, 2006
Study of Milnacipran for the Treatment of Fibromyalgia
NCT00098124COMPLETEDPHASE3
1.2K participants
INTERVENTIONAL
Birmingham, United States +79 more
Started: Nov 1, 2004
Evaluation of the Antinociceptive and Analgesic Effects of Milnacipran
NCT00757679COMPLETEDPHASE2
153 participants
INTERVENTIONAL
Geneva, Switzerland
Started: Sep 1, 2006
A Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional MRI in Patients With Fibromyalgia
NCT01173055COMPLETEDPHASE4
22 participants
INTERVENTIONAL
Ann Arbor, United States
Started: Jun 1, 2010
The Effect of Milnacipran in Patients With Fibromyalgia
NCT01108731COMPLETEDPHASE2, PHASE3
37 participants
INTERVENTIONAL
New York, United States
Started: Mar 1, 2010
FMS European Long-Term Study
NCT00757731COMPLETEDPHASE3
490 participants
INTERVENTIONAL
Pardubice, Czechia +9 more
Started: Sep 1, 2006
A Study Of Milnacipran In Patients With Fibromyalgia: Effects On 24 Hour Ambulatory Blood Pressure Monitoring
NCT00618956COMPLETEDPHASE3
321 participants
INTERVENTIONAL
Birmingham, United States +37 more
Started: Oct 1, 2007
Milnacipran and Neurocognition, Pain and Fatigue in Fibromyalgia : A 13-week Randomized, Placebo Controlled Cross Over Trial
NCT01829243COMPLETEDPHASE3
26 participants
INTERVENTIONAL
Durham, United States
Started: Jul 1, 2011
Study of Milnacipran for the Treatment of Fibromyalgia
NCT00314249COMPLETEDPHASE3
1.02K participants
INTERVENTIONAL
Tuscaloosa, United States +23 more
Started: Apr 1, 2006
The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia
NCT01234675COMPLETEDPHASE4
19 participants
INTERVENTIONAL
Middleburg Heights, United States
Started: Nov 1, 2010
Drug and Talk Therapy for Fibromyalgia
NCT01038323COMPLETEDPHASE4
58 participants
INTERVENTIONAL
Indianapolis, United States
Started: Dec 1, 2009
Showing 20 of 28 total trials